[Breakthrough T1D](https://www.breakthrought1d.org)

November 12, 2025 (Letter of Intent) | January 21, 2026 (Full proposal)

Up to $1,500,000 total over 3 years; larger budgets considered with strong justification.

Supports research using continuous ketone monitoring to address clinically relevant questions and improve outcomes in type 1 diabetes.

--- ## Description This grant opportunity from Breakthrough T1D seeks studies that utilize continuous ketone monitoring (CKM) to address clinically relevant questions about ketone dynamics in type 1 diabetes (T1D). The aim is to leverage advanced CKM technology to gain new insights into T1D pathophysiology, improve prevention of diabetic ketoacidosis (DKA), and enhance the quality of life for people with T1D. Research may explore the clinical significance of ketone patterns, integration of CKM with other diabetes management tools, educational strategies, and prediction or prevention of acute and long-term complications. Both interventional clinical trials and observational studies are supported, with an emphasis on innovative, clinically translatable findings. --- ## Due Dates - November 12, 2025: Letter of Intent deadline - January 21, 2026: Full proposal deadline Award notification: May 2026 Earliest anticipated project start: July 2026 --- ## Funding Amount - Maximum request: $1,500,000 total over up to 3 years - Larger budgets or longer durations may be considered with strong justification; discuss with scientific contact before applying - Indirect costs: - SRAs (nonprofits/academia): up to 10% of total request - IDDPs (industry): indirect costs not permitted - Projects with smaller budgets are also welcome; funding level should match project scope and available resources --- ## Eligibility - Open to domestic and foreign nonprofit organizations (universities, colleges, hospitals, research institutes, government units) and for-profit entities - Applicants must hold a doctoral degree (M.D., Ph.D., D.M.D., D.V.M., D.O., or equivalent) and have a faculty or equivalent research position - For-profit entities and industry-academic collaborations may apply under the Industry Discovery and Development Partnership (IDDP) mechanism (matching funds required; additional requirements apply) - Breakthrough T1D encourages applications from a diverse range of qualified investigators --- ## Application Process - **Letter of Intent (LOI):** - Required for all applicants - Submit online via RMS360 using the provided template - Limit: 2 pages - Indicate if you permit sharing LOI with Abbott (for possible device donation/co-funding) - **Full Proposal:** - By invitation only, following LOI approval - Use templates provided in RMS360 - Include all required information for review; human subjects research must address safety and compliance requirements - **Device Support:** - Eligible studies may receive donated Abbott CKM devices (dual glucose/ketone monitors), subject to review and permission to share application materials - Proposals using other CKM devices are also considered --- ## Additional Information - Studies must focus on T1D and use CKM to address clinically meaningful questions - Not eligible: studies solely on CKM device accuracy, preclinical CKM development, or non-T1D populations - Projects may leverage ongoing or planned studies; analysis of existing data is allowed - Regulatory compliance with HHS human subjects protection is required - Review criteria: significance, approach, innovation, investigator experience, and environment --- ## External Links - [Breakthrough T1D Funding Opportunities](https://www.breakthrought1d.org/explore-research/funding-opportunities/) - [Full RFA and Application Details (PDF)](https://www.breakthrought1d.org/wp-content/uploads/2025/10/RFA_CKM_Call_Doc.pdf) - [Breakthrough T1D Contact Page](https://www.breakthrought1d.org/contact-us/) --- ## Contact Information | Name | Role | Email | |-------------------------|---------------------------|--------------------------------| | Amin Ghavami Nejad, Ph.D. | Senior Scientist (Scientific Contact) | aghavami@BreakthroughT1D.org | | Michael Meyer, MPA | Senior Program Administrator (Administrative Contact) | mmeyer@BreakthroughT1D.org |

Breakthrough T1D Request for Applications: Studies addressing clinically relevant questions about ketones and the use of continuous ketone monitoring in type 1 diabetes

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