Centers without Walls for mechanisms of neurodegeneration in Alzheimer's disease-related dementias (ADRD)
This grant supports collaborative, multi-institutional research teams to uncover mechanisms of neurodegeneration in Alzheimer's-related dementias using diverse expertise, advanced technologies, and coordinated efforts.
Funder: National Institutes of Health
Due Dates (Anticipated): October 2026 (Full application deadline, projected)
Funding Amounts: Estimated total program funding: $10,000,000; ~5 awards expected; multi-year, center-scale support.
Summary: Supports collaborative, interdisciplinary research consortia to investigate mechanisms of neurodegeneration in Alzheimer’s disease-related dementias (ADRD).
Key Information: This is a forecasted opportunity; applications are not yet being solicited.
Description
The National Institute of Neurological Disorders and Stroke (NINDS), part of the NIH, anticipates supporting ambitious, multi-institutional research consortia under a "Centers without Walls" model to study mechanisms of neurodegeneration in Alzheimer’s disease-related dementias (ADRD). The program aims to break down disciplinary and institutional silos, encouraging teams with diverse expertise—spanning basic, translational, and clinical science—to collaboratively address the complexity, heterogeneity, and co-pathologies of ADRD.
Consortia are expected to leverage advanced technologies, disease-relevant models, and human specimens to uncover novel disease mechanisms, therapeutic targets, biomarkers, and factors influencing ADRD susceptibility and resilience. One funded team will serve as a coordinating center to facilitate cross-site communication, data harmonization, and reproducibility.
This opportunity is aligned with priorities from the ADRD Summit 2025 and is designed to lay the groundwork for future translational and clinical research in ADRD.
