Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE)
ARPA-H's CIRCLE program funds teams to use AI-driven digital twins and innovative diagnostics to track and modulate immune responses for better critical care outcomes in ICU patients.
Funder: Advanced Research Projects Agency for Health
Due Dates: March 30, 2026 (Solution Summaries) | May 22, 2026 (Questions) | May 28, 2026 (Full Proposals)
Funding Amounts: No set budget cap; multiple awards anticipated; project periods up to 5 years; budgets should match project scope and milestones.
Summary: Supports multidisciplinary teams to develop AI-driven digital twins and interventions to track and modulate immune responses for improved critical care outcomes.
Key Information: Only proposers who submitted a Solution Summary by March 30, 2026 are eligible to submit a full proposal.
Description
The Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) program, funded by ARPA-H, aims to transform the treatment of critical illness in intensive care units (ICUs) by leveraging advanced AI, digital twin technologies, and innovative diagnostics. The initiative targets the identification and modulation of immune system control points to enable more effective use of both current and next-generation immunotherapies, with the ultimate goal of reducing ICU stays, lowering associated costs, and improving patient outcomes. CIRCLE emphasizes the integration of multidisciplinary expertise—spanning clinical care, computational modeling, data platforms, and intervention modalities—to build comprehensive datasets, develop patient-specific computational models, and test interventions that modulate immune responses in real time.
