Clinical Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative UG3/UH3 Clinical Trial Required)
NIH plans to fund a Clinical Coordinating Center for multi-site clinical trials, requiring collaboration with a Data Coordinating Center and a comprehensive scientific plan.
Funder: National Institutes of Health
Due Dates: November 2, 2028
Funding Amounts: Award amounts not specified; cooperative agreement mechanism; multi-year, milestone-driven funding expected.
Summary: Supports Clinical Coordinating Centers for investigator-initiated, multi-site clinical trials relevant to the NHLBI mission.
Key Information: CCC and collaborating DCC applications must be submitted together for consideration.
Description
This funding opportunity supports the development and conduct of a Clinical Coordinating Center (CCC) for investigator-initiated, multi-site clinical trials, including efficacy, comparative effectiveness, pragmatic, and/or dissemination and implementation science trials. The program encourages the use of innovative trial designs (e.g., platform, adaptive, Bayesian) and seeks projects that address therapeutic, behavioral, or prevention strategies relevant to the National Heart, Lung, and Blood Institute (NHLBI) mission. The CCC is responsible for scientific rationale, operational planning, project management, recruitment, retention, milestone tracking, scientific conduct, results dissemination, and increasing community engagement throughout the trial lifecycle. Applicants must also submit a companion Data Coordinating Center (DCC) application in parallel.
