Collaborative Network for Clinical Research on Immune Tolerance
This grant supports clinical trials and research to improve understanding and treatment of immune tolerance in transplant rejection, autoimmune, allergic diseases, and asthma.
Funder: National Institutes of Health
Due Dates (Anticipated): January 2027 (Full application deadline, projected)
Funding Amounts: Estimated total program funding: $21,986,000; expected number of awards: 1; single large cooperative agreement
Summary: Supports a collaborative network to advance clinical research and interventions on immune tolerance in transplantation, autoimmune, and allergic diseases.
Key Information: This is a forecasted opportunity; all dates are projected and subject to change.
Description
The National Institute of Allergy and Infectious Diseases (NIAID), part of the NIH, intends to continue supporting a Collaborative Network for Clinical Research on Immune Tolerance. This program aims to deepen understanding of the mechanisms behind the induction, maintenance, and loss of immune tolerance in humans and to develop improved interventions for preventing and treating immune-mediated diseases. Target areas include transplant rejection (liver, kidney, pancreatic islet), autoimmune diseases, asthma, and allergic conditions.
The network will:
- Conduct clinical trials evaluating the safety and efficacy of promising tolerogenic strategies.
- Investigate basic mechanisms of immune tolerance as an integral component of these trials.
- Develop, refine, and validate immune assays to monitor tolerance induction, maintenance, and loss.
