[Breakthrough T1D](https://www.breakthrought1d.org)

January 9, 2025 (Proposal deadline)

Up to $150,000 total for 1 year, including up to 10% indirect costs

Funds proof-of-concept research on shared immune mechanisms across autoimmune diseases to foster collaboration and accelerate innovative therapies.

--- ## Description This funding opportunity supports proof-of-concept studies investigating shared or distinct immune mechanisms underlying multiple autoimmune diseases. The program is a collaboration between Breakthrough T1D, Lupus Research Alliance, and the National Multiple Sclerosis Society. Its goal is to promote interdisciplinary research that identifies novel mechanisms, validates therapeutic targets, and leverages large datasets or primary human samples to explore disease heterogeneity and biomarkers. Projects should lay the groundwork for future, larger-scale collaborative studies and ultimately aim to accelerate the development of effective treatments and cures for autoimmune diseases. --- ## Due Dates - January 9, 2025: Proposal deadline (full application) --- ## Funding Amount - Applicants may request up to $150,000 total for a one-year project, including up to 10% indirect costs. - Budgets should also include up to $2,500 for travel to a required in-person update meeting. --- ## Eligibility - Open to domestic and foreign non-profit organizations (universities, colleges, hospitals, laboratories), public and private entities, and eligible government agencies. - For-profit entities and industry-academic collaborations are eligible; additional information may be required if invited for a full application. - Applicants must hold an M.D., D.M.D., D.V.M., Ph.D., or equivalent and have a faculty or equivalent research position. - No citizenship restrictions apply. - Applications from individuals with disabilities, women, and underrepresented minorities are encouraged. --- ## Application Process - Proposals must be submitted online via the [RMS360 portal](https://www.breakthrought1d.org/explore-research/funding-opportunities/). - Use the provided proposal template from the RMS360 website. - No letter of intent is required. - All proposals will be reviewed by a joint steering committee and external scientific panel. - Applications must address at least two relevant autoimmune diseases (multiple sclerosis, systemic lupus erythematosus or its manifestations, and/or type 1 diabetes). - Projects must be feasible within a one-year timeframe; clinical trials are not eligible, but studies using clinical samples are allowed. --- ## Additional Information - Awardees must attend and present at an in-person meeting; travel costs (up to $2,500) should be included in the budget. - The program encourages the use of primary human samples, large datasets, and multi-omics approaches. - Proposals focused on only one autoimmune disease, clinical trials, or projects requiring more than one year will not be considered. --- ## External Links - [Program RFA (PDF)](https://www.breakthrought1d.org/wp-content/uploads/2024/10/Common-Mechanisms-RFA-FY25-Final.pdf) - [Breakthrough T1D Funding Opportunities](https://www.breakthrought1d.org/explore-research/funding-opportunities/) - [Breakthrough T1D Home](https://www.breakthrought1d.org) --- ## Contact Information | Name | Role | Email | |---------------------|--------------------------------|--------------------------------------------| | Joshua Vieth, Ph.D. | Senior Director, Research | [jvieth@BreakthroughT1D.org](mailto:jvieth@BreakthroughT1D.org) | | Michael Meyer | Senior Program Administrator | [mmeyer@BreakthroughT1D.org](mailto:mmeyer@BreakthroughT1D.org) |

RFA: Common Mechanisms in Autoimmunity Insight Awards - Breakthrough T1D

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