[Breakthrough T1D](https://www.breakthrought1d.org)

December 4, 2025: Letters of Intent (LOI) deadline

Funding amount not specified in public materials; award size and duration set by RFA and project scope.

Supports the development of continuous C-peptide monitoring technologies for real-time assessment of insulin secretion in type 1 diabetes and at-risk individuals.

--- ## Description This funding opportunity from Breakthrough T1D aims to accelerate the development of continuous C-peptide monitoring (CCPM) technologies. The initiative seeks innovative solutions to enable real-time or near-real-time assessment of endogenous insulin secretion in individuals with type 1 diabetes (T1D) or those at risk for T1D. The ultimate goal is to improve disease management, enable better therapeutic evaluation, enhance clinical trial endpoints, and advance mechanistic understanding of T1D by facilitating more precise and dynamic monitoring of C-peptide as a biomarker of insulin production. --- ## Due Dates - December 4, 2025: Letters of Intent (LOI) deadline If invited, full proposal deadlines and award timelines will be communicated directly to applicants following LOI review. --- ## Funding Amount - The specific funding amount and duration are not stated on the public program page or RFA summary. - Award size, allowable costs, and project duration are determined by the RFA and are commensurate with project scope and objectives. - Applicants should consult the detailed [RFA PDF](https://www.breakthrought1d.org/wp-content/uploads/2025/10/CCPM_RFA_Call_Document.pdf) for budget guidance. --- ## Eligibility - Open to domestic and foreign non-profit organizations, public and private universities, colleges, hospitals, laboratories, and eligible government agencies. - For-profit organizations may be eligible under specific mechanisms (see RFA and Grant Handbook). - Applicants must typically hold a doctoral degree (PhD, MD, DMD, DVM, DO, or equivalent) and a faculty or equivalent research position. - Multidisciplinary teams and collaborations (including engineering, clinical, translational research backgrounds) are encouraged. - There are no citizenship restrictions. --- ## Application Process 1. **Review the Grant Handbook:** Understand general requirements and policies ([Grant Handbook](https://www.breakthrought1d.org/granthandbook/)). 2. **Download and Read the RFA:** Ensure your concept aligns with program goals and technical expectations ([RFA PDF](https://www.breakthrought1d.org/wp-content/uploads/2025/10/CCPM_RFA_Call_Document.pdf)). 3. **Submit a Letter of Intent (LOI):** Use the online RMS360 portal ([RMS360](https://breakthrought1d.smartsimple.us/)) by December 4, 2025. Follow the format and length requirements in the RFA. 4. **Full Proposal (by invitation):** If your LOI is approved, you will be invited to submit a full proposal via RMS360, using provided templates and adhering to communicated deadlines. 5. **Review Process:** Applications are evaluated for innovation, feasibility, impact, and alignment with Breakthrough T1D’s mission and research priorities. --- ## Additional Information - All applications must be submitted in English via the [RMS360 portal](https://breakthrought1d.smartsimple.us/). - Institutional and applicant eligibility, budget guidelines, and detailed application instructions are provided in the [Grant Handbook](https://www.breakthrought1d.org/wp-content/uploads/2024/07/granthandbook.pdf). - Human subjects research must follow NIH and HHS regulations as outlined in the handbook. - Indirect costs, if allowed, are typically capped at 10% of direct costs. - Review and selection criteria emphasize significance, innovation, feasibility, and translational potential. - For-profit applicants may be subject to additional requirements (e.g., matching funds) under the Industry Discovery & Development Partnership (IDDP) mechanism. --- ## External Links - [Breakthrough T1D Funding Opportunities Overview](https://www.breakthrought1d.org/explore-research/funding-opportunities/) - [RFA PDF – CCPM Call Document](https://www.breakthrought1d.org/wp-content/uploads/2025/10/CCPM_RFA_Call_Document.pdf) - [Grant Handbook](https://www.breakthrought1d.org/granthandbook/) - [RMS360 Application Portal](https://breakthrought1d.smartsimple.us/) - [Privacy Policy](https://www.breakthrought1d.org/privacy/) --- ## Contact Information | Purpose | Contact/Resource | |-----------------------|---------------------------------------------------------------------------------------------------| | General Inquiries | [Contact Form](https://www.breakthrought1d.org/contact-us/) | | Programmatic/Scientific | Refer to contacts listed in the [RFA PDF](https://www.breakthrought1d.org/wp-content/uploads/2025/10/CCPM_RFA_Call_Document.pdf) or Grant Handbook | | Pre-award Support | preawardsupport@breakthrought1d.org | ---

Development of Continuous C-Peptide Monitoring Technologies

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