Development of Candidate Medical Countermeasures (MCMs) and Technologies Against Radiological/Nuclear or Chemical Threats (U01 Clinical Trial Not Allowed)
NIH funds research on radiation and chemical injuries, injury models, diagnostics, and medical countermeasures for radiological, nuclear, or chemical emergencies; clinical trials are not allowed.
This grant was recently updated
This grant has transitioned from forecasted to posted and is now accepting applications.
Funder: National Institutes of Health
Due Dates: November 9, 2026 (Applications) | October 8, 2027 (Applications) | October 9, 2028 (Applications)
Funding Amounts: Generally up to $350,000 in direct costs annually; Research Area 3 budgets expected not to exceed $2 million; maximum 5 years
Summary: Supports research and development of medical countermeasures, injury models, biodosimetry, and technologies addressing radiological/nuclear or chemical emergencies.
Key Information: Each application must address exactly one research area; clinical trials are not allowed.
Description
This NIH U01 cooperative agreement supports research from early discovery through advanced product development to diagnose, mitigate, or treat radiation- or chemical-induced injuries and internal radionuclide contamination. Led by the National Institute of Allergy and Infectious Diseases (NIAID), with NEI, NHLBI, NIAMS, NIDA, and NINDS participating, the program aims to develop practical triage tools and safe, effective medical countermeasures for mass-casualty public health emergencies.
The four research areas cover radiation countermeasures, models and natural history; biodosimetry; an existing nonhuman primate radiation survivor cohort; and chemical countermeasures. Across these areas, animal models and new approach methodologies—including computational models and in vitro platforms—may support injury characterization, biomarkers, and countermeasure safety and efficacy. Chemical countermeasure support focuses on discovery and early development against U.S. Government-designated Chemicals of Concern.
