Discovery of in vivo Chemical Probes for the Nervous System
This grant will fund research to discover and optimize new small-molecule chemical probes for novel brain targets to advance understanding of nervous system diseases.
Funder: National Institutes of Health
Due Dates: March 5, 2027
Funding Amounts: No specified ceiling or floor; typical R01 awards are multi-year and may range up to several hundred thousand dollars per year.
Summary: Supports discovery and development of in vivo chemical probes for novel brain targets to advance research on brain-related diseases and biological processes.
Description
This grant supports researchers in the discovery and development of in vivo chemical probes targeting novel brain mechanisms. The program aims to stimulate research on small molecules that can be used to understand biological processes relevant to the missions of the National Institute of Mental Health (NIMH), National Institute on Drug Abuse (NIDA), National Eye Institute (NEI), and National Institute on Aging (NIA). Projects should focus on chemical optimization of existing validated hits and bioassay development for testing new analogs. Emphasis is placed on studies that reveal new disease-related biological targets and processes, ultimately informing brain disease mechanisms.
