Funder: Dept. of the Army -- USAMRAA
Due Dates: August 8, 2025 (Pre-application/LOI) | August 29, 2025 (Full application)
Funding Amounts: Up to $10.5M for Coordinating Center (4 years); up to $2M per Clinical Research Site (4 years); ~12 awards; total program funding $32.5M.
Summary: Supports a multi-institutional consortium to rapidly execute phase 2 and phase 2-linked phase 1 clinical trials for novel prostate cancer therapeutics.
Key Information: Does not support clinical protocol development; applicants must address at least one FY25 PCRP Overarching Challenge.
Description
The FY25 Prostate Cancer Research Program (PCRP) Clinical Consortium Award funds the development, maintenance, and enhancement of a collaborative network to expedite phase 2 and phase 2-linked phase 1 clinical trials for prostate cancer. The primary goal is to accelerate the clinical advancement of novel therapeutic interventions by combining expertise and patient access across leading institutions. There are two main roles available: a single Coordinating Center (also serving as a Clinical Research Site) and multiple Clinical Research Sites. The Coordinating Center manages consortium operations, trial selection, regulatory and data management, and supports at least two affiliated sites with enhanced access to high-risk and/or military populations.
This mechanism is focused on trial execution and infrastructure—not clinical protocol development. Applications must directly address at least one of the FY25 PCRP Overarching Challenges (e.g., lethal disease progression, new/improved treatments, quality of life, or access to care with special emphasis on high-risk groups).
Due Dates
- Pre-application (Letter of Intent): August 8, 2025, 5:00 p.m. ET (required)
- Full Application: August 29, 2025, 11:59 p.m. ET
- Application Verification Deadline: September 3, 2025, 5:00 p.m. ET
Funding Amount
- Total Program Funding: $32,500,000 (anticipated)
- Coordinating Center: Up to $10.5M total costs over 4 years (1 award expected)
- Clinical Research Site: Up to $2M total costs over 4 years per site (approx. 11 awards expected)
- Affiliate Clinical Research Sites: Supported via the Coordinating Center (minimum $250,000/site/year)
Funds are for infrastructure and trial execution (not protocol development). No cost sharing is required.
Eligibility
- Organizations: Unrestricted. Open to U.S. and international, public or private, for-profit or nonprofit, academic, governmental, and research institutions.
- Principal Investigators: Must have a faculty-level (or equivalent) appointment at an eligible organization. No citizenship or nationality restrictions.
- Consortium Structure: Applicants must apply as either the Coordinating Center (also a Clinical Research Site) or as a Clinical Research Site. The Coordinating Center must also propose two or more Affiliate Clinical Research Sites with enhanced access to high-risk and/or military populations.
Application Process
- Registration: Active registrations in SAM.gov, eBRAP, and Grants.gov are required.
- Pre-application (LOI): Submit via eBRAP by August 8, 2025. No invitation is required to submit a full application.
- Full Application:
- Extramural (non-DoD) applicants submit via Grants.gov.
- Intramural DoD applicants submit via eBRAP.
- Application must include all required attachments (Project Narrative, technical and lay abstracts, statement of work, impact statement, data/resource sharing plan, etc.).
- Coordinating Center applications must include documentation for two initial funded clinical trials ready to launch within three months of award.
- Verification: After submission, verify application completeness in eBRAP by September 3, 2025.
- Review: Two-tier review process: peer review (scientific merit) and programmatic review (relevance and portfolio balance).
Additional Information
- Scope: Only supports phase 2 or phase 2-linked phase 1 trials; phase 3 or higher trials are not eligible.
- Trial Development: This award does not fund the development of new clinical protocols.
- Performance Metrics: Sites must meet annual accrual and participation benchmarks, including recruiting patients from high-risk and/or military populations.
- Sustainability: The Coordinating Center must propose a plan for financial sustainability beyond the award period.
- Reporting: Annual and final technical reports are required. Coordinating Center must provide Inclusion Enrollment Reports for all consortium trials.
External Links
Contact Information