Funder: Dept. of the Army -- USAMRAA
Due Dates: August 8, 2025 (Pre-application) | August 29, 2025 (Full application)
Funding Amounts: Established Investigators: up to $1.7M total for 3 years | New Investigators: up to $2.1M total for 4 years | ~17 awards; total program funding ~$30.5M
Summary: Supports innovative research ideas in prostate cancer, requiring alignment with specific overarching challenges of the Prostate Cancer Research Program (PCRP).
Key Information: Clinical trials are not allowed; New Investigators must include a prostate cancer research collaborator.
Description
This award supports innovative, high-impact research projects that address one or more of the FY25 Prostate Cancer Research Program (PCRP) overarching challenges. The intent is to fund new ideas that could significantly advance the field of prostate cancer research, improve patient care, or address critical gaps. Both established and early-career (New) investigators are encouraged to apply, with dedicated funding and review criteria for each group. All projects must address at least one of the PCRP’s specified challenges, such as reducing death from lethal prostate cancer, developing new therapies, improving quality of life, or enhancing access to optimal care.
Due Dates
- Pre-application (Letter of Intent) Deadline: August 8, 2025 (5:00 p.m. ET) via eBRAP
- Full Application Deadline: August 29, 2025 (11:59 p.m. ET) via Grants.gov or eBRAP (for DOD intramural applicants)
- End of Application Verification Period: September 3, 2025 (5:00 p.m. ET)
- Peer Review: October 2025
- Programmatic Review: February 2026
Funding Amount
- Total Program Funding: ~$30.5 million
- Expected Number of Awards: ~17
- Established Investigator Awards: ~13 awards, up to $1.7 million total costs each, max 3 years
- New Investigator Awards: ~4 awards, up to $2.1 million total costs each, max 4 years
Budget includes direct and indirect costs. No cost-sharing or matching required.
Eligibility
- Eligible Applicants: Unrestricted. Open to domestic and foreign, public and private, for-profit and non-profit organizations, including academic institutions, research organizations, and companies.
- Principal Investigator (PI):
- Each investigator may submit only one application as PI.
- Established Investigator: Independent researchers at any career stage.
- New Investigator: Within 10 years of terminal degree (excluding certain leaves), independent (not under formal mentorship), and must include a collaborator experienced in prostate cancer research.
- Graduate students and junior postdocs (<3 years postdoc) are not eligible as PI.
- Citizenship: No restrictions; international applicants allowed.
Application Process
Step 1: Pre-application (Letter of Intent)
- Submit via eBRAP.
- Briefly describe research and specify which PCRP overarching challenge(s) will be addressed.
- Required for all applicants; no invitation needed to proceed to full application.
Step 2: Full Application
- Submit via Grants.gov (extramural) or eBRAP (intramural DOD only).
- Key required components:
- Project Narrative (15 pages)
- Supporting documentation
- Technical and lay abstracts
- Statement of Work
- Impact and Innovation statements
- Eligibility documentation (for New Investigators)
- Inclusion plans (if clinical research)
- Transition plan
- Budget and justification
- Biographical sketches and current/pending support for key personnel
Note: Clinical trials are not permitted under this mechanism.
Additional Information
- Research Scope: Must address at least one of the FY25 PCRP overarching challenges:
- Biology of lethal prostate cancer progression
- New/improved therapies for lethal prostate cancer
- Quality of life for patients and families
- Access to optimal care, especially for high-risk groups
- Innovation & Impact: Projects must go beyond incremental advances and have clear potential for significant impact.
- Collaboration: Multidisciplinary and multi-institutional projects are encouraged. New Investigator applications must include a prostate cancer expert collaborator.
- Review Process: Two-tier review (peer and programmatic), with key criteria including innovation, impact, research strategy, feasibility, and personnel.
- Restrictions: No clinical trials; no more than one application per PI; project must not duplicate other funded projects.
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Contact Information