[Alzheimer's Drug Discovery Foundation](https://www.alzdiscovery.org)

January 12, 2026 (Invited Full Proposal) | September 14, 2026 (Letter of Intent)

Up to $5,000,000 per project; multi-year awards; only direct costs allowed.

Supports IND-enabling studies and early-phase clinical trials for novel or repurposed therapies targeting Alzheimer's disease and related dementias.

--- ## Description This opportunity funds investigational new drug (IND)-enabling studies and early-phase clinical trials for promising pharmacological interventions and devices aimed at treating Alzheimer's disease and related dementias. The program is open to a broad range of therapeutic modalities—including small molecules, peptides, antibodies, gene therapies, antisense oligonucleotides, stem cells, and devices—with a focus on novel mechanisms or modes of action relevant to the biology of aging or other emerging dementia-related pathways. Both disease-modifying and symptomatic agents are considered, with a strong emphasis on intellectual property development and translational potential. Applications should be supported by preclinical and/or clinical data, and collaboration across organizations is encouraged. --- ## Due Dates - January 12, 2026: Invited full proposal deadline - September 14, 2026: Letter of Intent deadline *All applications must be received by 5:00 pm ET on the deadline date.* --- ## Funding Amount - Maximum award: Up to $5,000,000 per project, depending on stage and scope. - Average duration: Multi-year awards. - Allowable costs: Only direct costs (personnel, supplies, small non-durable equipment up to $2,500, consultants, and patient costs for clinical trials); no indirect/overhead costs, capital equipment, publication costs, or travel (unless pre-approved). - Payment structure: Negotiated based on milestone achievements and recruitment. - Co-funding: Encouraged for projects requiring additional support. --- ## Eligibility - Open to researchers and clinicians worldwide. - Eligible institutions: - Academic medical centers, universities, and nonprofit organizations - Biotechnology companies (existing or new startups) - Industry partnerships are encouraged. - Funding is provided through mission-related investments requiring a return based on scientific/business milestones. - Restrictions: - One LOI and one full proposal per cycle per applicant/company. - Non-pharmacologic interventions (diet, meditation, exercise) are not eligible. - Anti-amyloid and cholinesterase inhibitor approaches are not considered. --- ## Application Process 1. **Letter of Intent (LOI):** - Submit through the [ADDF Funding Portal](https://addf.fluxx.io/). - Briefly describe rationale, aims, and key supporting data (each section up to 300 words). - Notification of invitation to submit a full proposal typically within 2–3 weeks. 2. **Full Proposal (by invitation):** - Submit via the [ADDF Funding Portal](https://addf.fluxx.io/). - Detailed narrative (up to 20 pages), budget (Excel), biosketches, and relevant forms. - For biotech companies: submit a business packet. - Review process: External scientific/business review boards; final decision within 3–4 months of proposal submission. 3. **Resubmissions:** Up to two resubmissions allowed if reviewer concerns are addressed. 4. **Clinical Trials:** Must register and submit results on [ClinicalTrials.gov](https://register.clinicaltrials.gov/). --- ## Additional Information - Strong applications provide compelling preclinical/clinical evidence, robust study design (with biostatistical input), and a clear IP strategy. - Detailed landscape analysis of the therapeutic approach is encouraged. - Collaboration with other investigators or contract research organizations is recommended. - Only direct costs are funded; see [Funding Policies](https://www.alzdiscovery.org/research-and-grants/funding-opportunities/policies) for details. --- ## External Links - [Program Details & RFP](https://www.alzdiscovery.org/research-and-grants/funding-opportunities/drug-development-rfp) - [Application Instructions](https://www.alzdiscovery.org/research-and-grants/funding-opportunities/application-instructions) - [Funding Policies](https://www.alzdiscovery.org/research-and-grants/funding-opportunities/policies) - [ADDF Funding Portal (Apply)](https://addf.fluxx.io/) - [Our Research Strategy](https://www.alzdiscovery.org/research-and-grants/our-research-strategy) --- ## Contact Information | Contact | Email | Phone | Online Contact Form | |------------------------|-------------------------------|-----------------|------------------------------------------------------------------| | ADDF Grants & Mission-Related Investments Team | grants@alzdiscovery.org | 212.901.8000 | [Contact Us](https://www.alzdiscovery.org/contact-us) | | General Information | info@alzdiscovery.org | | |

Drug Development RFP - Alzheimer's Drug Discovery Foundation

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