[National Institutes of Health (NIH)](https://www.nih.gov/)

September 25, 2025 (forecasted)

Estimated total funding: $2,500,000 | Expected number of awards: 1 | U54 Cooperative Agreement

Supports the creation of a central infrastructure hub to accelerate and support medication repurposing and repositioning for substance use disorder (SUD) research.

This is a forecasted opportunity; applications are not yet being solicited.

--- ## Description The National Institute on Drug Abuse (NIDA), part of the NIH, intends to support the establishment and operation of a dynamic, adaptable drug development infrastructure (envisioned as a Center) to aid the research community in advancing medication repurposing and repositioning efforts for substance use disorders (SUDs). The Center will function as a hub, offering comprehensive services to academic and biotech researchers at all product development stages. Services will include: - Creation of Target Product Profiles - Freedom-to-Operate analyses - Intellectual property consultations - Regulatory guidance - Technical pipeline support The overarching goal is to strengthen and expand the SUD drug development pipeline by accelerating the evaluation and validation of repurposed and repositioned drugs. The anticipated Notice of Funding Opportunity (NOFO) aims to give potential applicants time to develop collaborations and responsive projects. Collaborative teams with expertise in pharmacology, toxicology, neuroscience, drug development, in silico discovery, target validation, preclinical/clinical development, regulatory affairs, and IP management are encouraged to consider applying. **Note:** This is a forecasted opportunity; the official NOFO and application instructions are not yet available. --- ## Due Dates - **Forecasted Application Due Date:** September 25, 2025 - The NOFO is expected to be published on or after July 25, 2025. --- ## Funding Amount - **Estimated Total Program Funding:** $2,500,000 - **Expected Number of Awards:** 1 - **Funding Mechanism:** U54 Cooperative Agreement - **Project Start Date (estimated):** July 1, 2026 - **Cost Sharing/Matching:** Not required --- ## Eligibility Eligible applicants include: - State governments - County governments - Independent school districts - Public and State-controlled institutions of higher education - Native American tribal governments (federally recognized and other) - Public housing authorities/Indian housing authorities - Nonprofits (without 501(c)(3) status), other than IHEs - Private institutions of higher education - For-profit organizations (including small businesses) --- ## Application Process - This is a forecasted opportunity; applications are **not yet being accepted**. - The official Notice of Funding Opportunity (NOFO) will provide detailed application instructions once published. - Prospective applicants are encouraged to begin developing collaborations and project concepts now. --- ## Additional Information - Clinical trials are **not allowed** under this opportunity. - The Center is expected to provide outreach and support to the research community, particularly in SUD drug development. - Investigators with relevant expertise are strongly encouraged to prepare for the forthcoming NOFO. --- ## External Links - [Official Grants.gov Listing (FOR-DA-26-005)](https://www.grants.gov/search-results-detail/359125) - [NIH Main Website](https://www.nih.gov/) --- ## Contact Information | Name | Email | Phone | Affiliation | |-------------------------------|-----------------------------------------------|---------------|------------------------------------| | Saravanan Karuppagounder, PhD | [saravanan.karuppagounder@nih.gov](mailto:saravanan.karuppagounder@nih.gov) | 301-480-9471 | National Institute on Drug Abuse |

Dynamic and Adaptable Infrastructure for Drug Development and Outreach to Aid the Research Community in Advancing Medication Repurposing and Repositioning Efforts for substance use disorders (SUDs) (U54 - Clinical Trials Not Allowed)

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