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    Early-Onset Cancers: Investigating Etiology, Mechanisms, and Early Detection Strategies (RP1 Clinical Trials Optional)

    This grant funds research on causes, biological mechanisms, and early detection of non-hereditary early-onset cancers (ages 18-49) to inform prevention and control strategies.

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    This grant was recently updated

    This grant has transitioned from forecasted to posted and is now accepting applications.

    Funder: National Institutes of Health

    Due Dates: October 11, 2029 (Closing date for applications)

    Funding Amounts: No cost sharing or matching required

    Summary: Supports research on the causes, biological mechanisms, and risk identification of sporadic non-hereditary early-onset cancers in adults ages 18–49.

    Key Information: Applications involving foreign subawards or subcontracts will not be considered for funding.


    Description

    This National Institutes of Health opportunity supports research into sporadic, non-hereditary early-onset cancers in adults ages 18–49. It seeks to explain the rise of cancers in young adults and inform prevention and control strategies. The program supports both exploratory/developmental and standard research projects through the RP1 grant mechanism. Clinical trials are optional.

    Studies should address one or more of three areas: environmental or lifestyle exposures driving increased incidence, including differences by patient demographics; biological mechanisms and host responses underlying the increase; or more effective identification of people at increased risk. The emphasis is on understanding cancer etiology and mechanisms alongside strategies for identifying risk earlier.


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