Funder: National Institutes of Health
Due Dates: June 17, 2025 | October 15, 2025 | February 13, 2026 | June 15, 2026 | October 15, 2026 | February 17, 2027 | June 15, 2027 | October 15, 2027
Funding Amounts: No budget cap; up to 5 years total (2 years R61, 3 years R33); $27M total program funding (FY26, across NOFOs)
Summary: Supports early-stage clinical trials of novel pharmacologic or neuromodulatory device-based interventions for mental disorders, requiring both clinical effect and mechanistic evaluation.
Key Information: R61/R33 biphasic structure; clinical trial required; both phases must be proposed; foreign and domestic applicants eligible.