[National Institutes of Health (NIH)](https://www.nih.gov)

October 30, 2025 (anticipated)

$850,000 total program funding; 1 expected award; U24 Cooperative Agreement

Supports a Pharmacokinetics Resource Laboratory to advance clinical development of NCI IND agents within the Experimental Therapeutics Clinical Trials Network (ETCTN).

This is a forecasted opportunity; applications are not yet being solicited.

--- ## Description The National Cancer Institute (NCI) intends to publish a Notice of Funding Opportunity (NOFO) to support the establishment or maintenance of a Pharmacokinetics (PK) Resource Laboratory for the Experimental Therapeutics Clinical Trials Network (ETCTN). The PK Laboratory will provide comprehensive support for biospecimen collection, pharmacokinetic analyses, drug-drug and cytochrome P450 (CYP) interactions, pharmacodynamics, and food effects in ETCTN studies of NCI Investigational New Drug (IND) agents. The overarching aim is to advance the clinical development of NCI IND agents by delivering a robust understanding of their pharmacokinetic behavior in early-phase clinical trials. The funded laboratory will be expected to have infrastructure in place to support all PK studies from trial initiation through clinical development. Applicants must propose three functional components: - **Technical Services Core:** Full range of PK and associated assays/analyses to support ETCTN clinical trials. - **Scientific Leadership and Project Development Core:** Scientific leadership and expertise to foster a team-science approach for PK activities. - **Biospecimen Collection, Tracking, Processing, and Data Reporting Core:** Integrated system for biospecimen management and data reporting from ETCTN sites. This is a forecasted opportunity; the NOFO is expected to be published in Summer 2025, with the application due date anticipated for Fall 2025. --- ## Due Dates - Anticipated application due date: October 30, 2025 *All dates are projected based on the annual cycle; check the program page for updates.* --- ## Funding Amount - Estimated total program funding: $850,000 - Expected number of awards: 1 - Funding mechanism: U24 Cooperative Agreement - No cost sharing or matching requirement --- ## Eligibility Eligible applicants include: - Public and State controlled institutions of higher education - Private institutions of higher education - Nonprofits with 501(c)(3) status (other than institutions of higher education) Applicants must have established infrastructure to support PK studies for ETCTN clinical trials. --- ## Application Process - Applications are not currently being solicited. - The NOFO will be published in Summer 2025. - Interested applicants should use this advance notice to develop collaborations and prepare responsive projects. - Monitor [Grants.gov opportunity page](https://www.grants.gov/search-results-detail/359854) for updates and application instructions once the NOFO is released. --- ## Additional Information - This opportunity uses the U24 activity code (Resource-Related Research Projects – Cooperative Agreements). - The PK Laboratory will be expected to serve as a centralized resource for all ETCTN early-phase clinical trials involving NCI IND agents. - Applicants should demonstrate multidisciplinary expertise and capacity for team-science approaches. --- ## External Links - [NIH – National Institutes of Health](https://www.nih.gov) - [Official Grants.gov Opportunity Listing](https://www.grants.gov/search-results-detail/359854) - [NCI Division of Cancer Treatment and Diagnosis](https://dctd.cancer.gov/) - [Cancer Therapy Evaluation Program (CTEP)](https://ctep.cancer.gov/) --- ## Contact Information | Name | Email | Phone | Affiliation | |-----------------------|--------------------------------------------|---------------|----------------------------| | Lori A. Henderson, Ph.D. | [NCIETCTNRFA@mail.nih.gov](mailto:NCIETCTNRFA@mail.nih.gov) | 240-276-5930 | National Cancer Institute |

Forecast to Publish a Notice of Funding Opportunity for The Experimental Therapeutics Clinical Trials Network (ETCTN) Pharmacokinetic Resource Laboratory (U24 Clinical Trial Not Allowed)

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