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    Exploration – Hypothesis Development Award (Multiple Sclerosis Research Program, FY26)

    Funds early-stage, innovative research to advance understanding and treatment of multiple sclerosis, emphasizing novel, high-risk concepts in disease mechanisms and biology.

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    Funder: Military Health System Research Program

    Due Dates (Anticipated): June 2026: Letter of Intent | June 2026: Pre-application (eBRAP) | August 2026: Full application (Grants.gov)

    Funding Amounts: Up to $250,000 total costs for a maximum of 2 years; no clinical trials allowed.

    Summary: Supports early-stage, high-risk, innovative research to address key gaps in multiple sclerosis understanding and treatment.

    Key Information: Letter of intent and pre-application required; final details to be confirmed in official announcement.


    Description

    This opportunity supports the initial investigation of innovative, high-risk, and potentially groundbreaking concepts in multiple sclerosis (MS) research. The program is designed to encourage novel approaches that address fundamental gaps in MS understanding, with a focus on areas such as central nervous system repair, disease activity and progression, symptom biology and measurement, and mechanisms associated with disease onset and course. Emphasis is placed on the strength and innovation of the proposed approach rather than preliminary data. Clinical trials are not permitted under this mechanism. The award is open to established investigators at any career stage, as well as new investigators early in their faculty appointments.


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