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    Exploratory Clinical Neuroscience Research on Substance Use Disorders

    This grant funds exploratory clinical neuroscience research to uncover neurobiological mechanisms of substance use disorders, supporting larger budgets and offering clinical trial options.

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    Funder: National Institutes of Health

    Due Dates (Anticipated): July 2026 (Full application deadline, projected)

    Funding Amounts: Expected 6 awards; budgets may exceed R21 limits; duration and ceiling not specified.

    Summary: Supports exploratory and developmental clinical neuroscience research on the neurobiological mechanisms underlying substance use disorders (SUD).

    Key Information: This is a forecasted opportunity; all dates and details are projected and subject to change.


    Description

    This Notice of Funding Opportunity (NOFO) utilizes the R61/R33 Phased Innovation Award mechanism to support clinical research applications that are exploratory and developmental in nature, focusing on understanding the neurobiological mechanisms underlying substance use disorders (SUD), including fundamental brain function relevant to substance use. The program is specifically intended for projects requiring budgets that exceed those allowed for the R21 mechanism, enabling more ambitious exploratory or developmental neuroscience research relevant to drug abuse and addiction.


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