[National Institutes of Health (NIH)](https://www.nih.gov/)

February 17, 2026 (estimated)

Award size not yet specified; funding instrument is a Cooperative Agreement.

Supports translational research on extracellular vesicle-based therapeutics for regenerative medicine, including direct and engineered EV therapies.

Forecasted opportunity—dates and details subject to change.

--- ## Description The National Center for Advancing Translational Sciences (NCATS) at NIH is forecasting a funding opportunity to support research on extracellular vesicle (EV) therapeutics in regenerative medicine. This initiative aims to advance the translation of EV-based therapeutics, such as exosomes and microvesicles, as novel, cell-free tools for tissue repair and regeneration. The program encourages proposals on both direct EV therapies (e.g., stem cell-derived EVs produced under Good Laboratory Practice conditions for off-the-shelf use) and designer EVs personalized to patient needs. Projects may involve engineering EVs to deliver therapeutic agents or modulate regenerative signaling pathways. --- ## Due Dates - Estimated Application Due Date: February 17, 2026 *All dates are projected based on the annual cycle; check the program page for updates.* --- ## Funding Amount - Award size and total program funding are not yet specified. - Funding instrument: Cooperative Agreement. - No cost sharing or matching requirement. --- ## Eligibility Eligible applicants include: - State governments - County governments - Independent school districts - Public and State controlled institutions of higher education - Native American tribal governments (Federally recognized) - Native American tribal organizations (other than Federally recognized tribal governments) - Public housing authorities/Indian housing authorities - Nonprofits with 501(c)(3) status (excluding institutions of higher education) - Private institutions of higher education - For-profit organizations (including small businesses) --- ## Application Process - This is a forecasted opportunity; the official Notice of Funding Opportunity (NOFO) is expected to be posted in October 2025. - Applicants should monitor [Grants.gov](https://www.grants.gov/search-results-detail/359866) and the NCATS website for updates and the official application instructions. - Prepare to submit a detailed proposal addressing translational research on EV therapeutics for regenerative medicine. --- ## Additional Information - The program is authorized under 42 U.S. Code § 287a - Cures Acceleration Network. - Areas of interest include both direct and engineered EV therapies aimed at advancing regenerative medicine. - This is a cooperative agreement, indicating substantial programmatic involvement by NIH staff. --- ## External Links - [View Forecasted Opportunity on Grants.gov](https://www.grants.gov/search-results-detail/359866) - [National Center for Advancing Translational Sciences (NCATS)](https://ncats.nih.gov/) - [NIH Main Website](https://www.nih.gov/) --- ## Contact Information | Name | Email | Phone | Affiliation | |---------------------|----------------------------------------|---------------|-------------------------------------------------| | Christine Happel, Ph.D. | [christine.happel@nih.gov](mailto:christine.happel@nih.gov) | 240-472-7550 | National Center for Advancing Translational Sciences (NCATS) |

Extracellular Vesicle Therapeutics for Regenerative Medicine (ExTReMe)

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