Research Grant Awards

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Description

The Fanconi Cancer Foundation (FCF) offers Research Grant Awards (RGA) to fund innovative, interdisciplinary, and translational research projects aimed at advancing understanding and treatment of Fanconi anemia (FA). The foundation prioritizes projects that address:

• The pathogenesis of cancers associated with FA, including prevention, early detection, treatment, and cure strategies.
• Development of novel gene therapy and gene editing technologies (ex vivo and in vivo) for FA.
• Identification of factors predictive of bone marrow failure, myelodysplastic syndrome, and leukemia in FA patients, and associated treatments.
• Understanding and managing systemic, inflammatory, and aging manifestations of FA, such as Fanconi Anemia Neurological Syndrome (FANS), endocrine, and fertility issues.
• Improving quality of life through practical management strategies for individuals and families affected by FA.
• Use of data analytics to identify biomarkers, risk predictions, and treatment hypotheses.
• Development and sharing of research resources like tissue samples, cell lines, model systems, and data.

Projects may be preclinical or clinical and should be milestone-based, with funding released in installments upon achievement of predefined milestones.

Due Dates

• January 3, 2025: Letter of Intent (LOI) submissions open
• March 12, 2025: LOI submission deadline (no late LOIs accepted)
• April 16, 2025: Invitations for full proposals sent
• June 23, 2025: Full proposal submission deadline
• October 31, 2025: Project start date

Funding Amount

• Awards range from $25,000 to $250,000 per project
• Funding duration is typically 1 to 2 years
• Budgets must be milestone-based, with funding released upon milestone completion
• PI salary can be included
• Indirect costs are not covered
• Grants support both preclinical and clinical research
• Not intended for startup funds to establish new laboratories

Eligibility

• Researchers with a PhD, MD, or equivalent degree from US or international academic, nonprofit, or for-profit institutions
• Early stage investigators (within first 5 years of first academic appointment at Assistant Professor level or equivalent) are encouraged to apply
• Both new and previously funded investigators in the FA field are eligible
• Collaboration across institutions and between early stage and senior investigators is encouraged

Application Process

1. Letter of Intent (LOI):

   • Submit via the official LOI Submission Form
   • Must clearly outline specific aims and relevance to FCF research priorities
   • Strict adherence to LOI guidelines is required
   • Multiple LOIs can be submitted

2. Full Proposal Invitation:

   • Selected applicants invited by April 16, 2025
   • Detailed instructions and review criteria provided

3. Full Proposal Submission:

   • Due June 23, 2025
   • Must include milestone-based budgets

4. Review and Selection:

   • External peer review followed by evaluation by a committee including FA experts and community representatives
   • Final funding decisions made by FCF Board of Directors
   • Funding notifications approximately 4 months after full proposal deadline

Additional Information

• Preliminary data is not required but improves funding chances
• Funded investigators must submit 6-month progress reports
• FCF supports projects that often would not be funded by NIH or other federal agencies
• The foundation encourages innovative projects with potential for significant impact on FA understanding and clinical care
• Investigators can collaborate and submit multiple proposals

External Links

• Fanconi Cancer Foundation Home
• Apply for Grant Funding
• LOI Submission Form
• Instructions for Scientific Reviewers (PDF)
• Contact Fanconi Cancer Foundation

Contact Information