[National Institutes of Health](https://www.nih.gov)

October 15, 2026 (anticipated)

R33 mechanism; specific award size not announced—see forthcoming NOFO for details.

Supports multisite feasibility studies of mind and body interventions on whole person health restoration, focusing on foundational work for future clinical trials.

This is a forecasted opportunity; applications are not yet being accepted.

--- ## Description This anticipated funding opportunity from the National Center for Complementary and Integrative Health (NCCIH) at NIH will support multisite feasibility studies of mind and body interventions (such as meditation, yoga, acupuncture, music, or multicomponent approaches) aimed at whole person health restoration. The goal is to lay the groundwork for future large-scale clinical efficacy and effectiveness trials, including investigation of mechanisms underlying emotional well-being (EWB). Key expectations include: - Delivering the intervention with fidelity across at least two geographically distinct sites. - Demonstrating reproducibility and rigor in engaging EWB mechanisms across sites. - Assessing feasibility of participant recruitment, retention, and randomization. - Collecting comprehensive clinical and mechanistic data at all sites. - Exploring correlations between mechanistic targets and clinical outcomes. Applicants are required to use the Whole Person Health Index as a clinical outcome measure, with the option to include additional relevant clinical outcomes. The focus is on feasibility testing in real-world, multisite settings, complementing other NCCIH mechanistic clinical trial opportunities. Multidisciplinary teams are especially encouraged to apply. --- ## Due Dates - October 15, 2026 (anticipated) *All dates are projected based on the annual cycle; check the program page for updates.* --- ## Funding Amount - The opportunity will use the R33 Clinical Trial Required mechanism. - Specific funding amounts and project durations will be detailed in the forthcoming Notice of Funding Opportunity (NOFO). - No cost sharing or matching required. --- ## Eligibility Eligible applicant types include: - State governments - County governments - Independent school districts - Public and State controlled institutions of higher education - Native American tribal governments (Federally recognized) - Public housing authorities/Indian housing authorities - Native American tribal organizations (other than Federally recognized tribal governments) - Nonprofits with 501(c)(3) IRS status (excluding higher education institutions) - Private institutions of higher education - For-profit organizations (excluding small businesses) - Small businesses Multidisciplinary teams with expertise in complementary and integrative health, clinical trial design, and mechanistic research are encouraged. --- ## Application Process - This is a forecasted opportunity; applications are not currently being accepted. - The official Notice of Funding Opportunity (NOFO) will provide detailed application instructions and requirements when released. - Prospective applicants should begin developing collaborative, multisite project plans in anticipation of the announcement. --- ## Additional Information - Studies must be conducted across at least two geographically distinct sites. - Use of the Whole Person Health Index is required; additional outcome measures may be included as relevant. - This NOFO is distinct from PAR-25-449, which supports mechanistic clinical trials. --- ## External Links - [NIH Funder Home Page](https://www.nih.gov) - [NIH About & Contact](https://www.nih.gov/about-nih/contact-nih) - [Grants.gov Opportunity Listing](https://www.grants.gov/search-results-detail/359941) --- ## Contact Information | Name | Email | Phone | Affiliation | |-----------------------------|--------------------------------------|---------------|-------------------------------------------------------------------------| | Jennifer N. Baumgartner, Ph.D. | jennifer.baumgartner@nih.gov | 301-402-4084 | National Center for Complementary and Integrative Health (NCCIH), NIH |

Assessing the Feasibility of Incorporating Mechanisms in Multisite Clinical Trials of Mind and Body Interventions on Whole Person Health Restoration (R01 Clinical Trial Required)

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