Assessing the Feasibility of Incorporating Mechanisms in Multisite Clinical Trials of Mind and Body Interventions on Whole Person Health Restoration (R01 Clinical Trial Required)
This grant will fund multisite feasibility studies testing whether mind and body interventions like meditation or yoga can be reliably delivered and measured for their effects on whole person health restoration.
Funder: National Institutes of Health
Due Dates: October 15, 2026 (anticipated)
Funding Amounts: R33 mechanism; specific award size not announced—see forthcoming NOFO for details.
Summary: Supports multisite feasibility studies of mind and body interventions on whole person health restoration, focusing on foundational work for future clinical trials.
Key Information: This is a forecasted opportunity; applications are not yet being accepted.
Description
This anticipated funding opportunity from the National Center for Complementary and Integrative Health (NCCIH) at NIH will support multisite feasibility studies of mind and body interventions (such as meditation, yoga, acupuncture, music, or multicomponent approaches) aimed at whole person health restoration. The goal is to lay the groundwork for future large-scale clinical efficacy and effectiveness trials, including investigation of mechanisms underlying emotional well-being (EWB).
Key expectations include:
- Delivering the intervention with fidelity across at least two geographically distinct sites.
- Demonstrating reproducibility and rigor in engaging EWB mechanisms across sites.
- Assessing feasibility of participant recruitment, retention, and randomization.
- Collecting comprehensive clinical and mechanistic data at all sites.
- Exploring correlations between mechanistic targets and clinical outcomes.
Applicants are required to use the Whole Person Health Index as a clinical outcome measure, with the option to include additional relevant clinical outcomes. The focus is on feasibility testing in real-world, multisite settings, complementing other NCCIH mechanistic clinical trial opportunities. Multidisciplinary teams are especially encouraged to apply.
