[National Institutes of Health (NIH)](https://www.nih.gov/)

February 5, 2026 (anticipated)

R01 mechanism; award size and duration to be announced in the full NOFO

Supports multisite feasibility studies of mind and body interventions (e.g., meditation, yoga, acupuncture) for whole person health restoration, focusing on mechanisms underlying emotional well-being.

This is a forecasted opportunity; details may change when the official NOFO is released.

--- ## Description The National Center for Complementary and Integrative Health (NCCIH) at NIH intends to support multisite feasibility studies assessing mind and body interventions (such as meditation, yoga, acupuncture, music, or multicomponent approaches) on whole person health restoration. The primary aim is to lay the groundwork for future large-scale clinical trials by establishing whether such interventions can be delivered with fidelity and rigor across multiple geographically distinct sites, and by evaluating their impact on both clinical outcomes and mechanisms related to emotional well-being (EWB). Key expectations for funded studies include: - Demonstrating intervention fidelity across sites - Ensuring reproducibility and rigor in engaging targeted EWB mechanisms - Assessing feasibility of recruitment, retention, and randomization across sites - Collecting comprehensive clinical and mechanistic data - Exploring correlations between mechanistic target changes and clinical outcomes Applicants will be required to use the Whole Person Health Index as a clinical outcome measure, though additional relevant outcomes may be included. This initiative complements other NCCIH opportunities focused on mechanistic clinical trials by emphasizing feasibility testing in real-world, multisite settings. --- ## Due Dates - Estimated application due date: February 5, 2026 *All dates are projected based on the annual cycle; check the program page for updates.* --- ## Funding Amount - Funding mechanism: R01 Clinical Trial Required - Expected award size and duration: To be specified in the forthcoming Notice of Funding Opportunity (NOFO) --- ## Eligibility Eligible applicants include: - State governments - County governments - Independent school districts - Public and State controlled institutions of higher education - Private institutions of higher education - Native American tribal governments (Federally recognized) - Native American tribal organizations (other than Federally recognized tribal governments) - Public housing authorities/Indian housing authorities - Nonprofits with 501(c)(3) status (excluding institutions of higher education) - For-profit organizations (excluding small businesses) - Small businesses --- ## Application Process - This is a forecasted opportunity; applications are not being solicited at this time. - The official NOFO will be published with detailed application instructions. - Multidisciplinary teams with experience in complementary/integrative health, clinical trial design, and mechanistic research are encouraged to prepare collaborative project plans in anticipation of the release. --- ## Additional Information - Studies must be conducted at a minimum of two geographically distinct sites to enhance generalizability and reproducibility. - The Whole Person Health Index is required as a clinical outcome measure. - This opportunity is intended to facilitate feasibility testing prior to larger efficacy/effectiveness trials. --- ## External Links - [Opportunity Forecast on Grants.gov](https://www.grants.gov/search-results-detail/359941) - [NCCIH - National Center for Complementary and Integrative Health](https://nccih.nih.gov/) --- ## Contact Information | Name | Email | Phone | Affiliation | |-----------------------------|---------------------------------------|--------------|-------------------------------------------------------| | Jennifer N. Baumgartner, Ph.D. | [jennifer.baumgartner@nih.gov](mailto:jennifer.baumgartner@nih.gov) | 301-402-4084 | National Center for Complementary and Integrative Health (NCCIH) | ---

Assessing the Feasibility of Incorporating Mechanisms in Multisite Clinical Trials of Mind and Body Interventions on Whole Person Health Restoration (R01 Clinical Trial Required)

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