[Beckman Foundation](https://www.beckman-foundation.org)

February 26, 2021 (Eligibility form) | June 11, 2021 (Full proposal)

Up to $1.5 million per institution; flexible use for equipment, personnel, and research costs.

Supports procurement and development of instrumentation and technology for advanced cellular Cryo-ET imaging workflows.

One-time program; eligibility form required before full proposal submission.

--- ## Description This grant program, administered by the Beckman Foundation, was designed to advance cellular cryo-electron tomography (Cryo-ET) by supporting the acquisition and development of focused ion beam (FIB) milling equipment, cryogenic light microscopes, Cryo-EM energy filters or detectors, and related sample preparation technologies. The program emphasized technology development within the Cryo-ET workflow, interdisciplinary teams, inclusion of data science expertise, and training opportunities for junior scientists. Proposals needed to address core biological problems enabled by these advanced imaging capabilities and include detailed plans for data storage, analysis, and risk mitigation for technology development. --- ## Due Dates - February 26, 2021: Eligibility determination submission deadline (eligibility form) by 1 pm Pacific/4 pm Eastern - June 11, 2021: Full proposal submission deadline by 1 pm Pacific/4 pm Eastern --- ## Funding Amount - Up to $1.5 million per institution (or per lead institution in a consortium) - Funds are flexible and may be used for: - Instrumentation acquisition, development, and maintenance - Support for personnel, junior scientists, and training programs - Data science collaborations and data storage infrastructure - Costs associated with the proposed research program - Institutions must demonstrate commitment for any additional funding required to complete project objectives --- ## Eligibility - Only nonprofit US universities or research institutions are eligible to apply, either individually or as consortia (with a US lead institution). - Applicants must: - Have existing or near-future plans for Cryo-ET capability (e.g., operational equipment, committed junior faculty, or track record with Cryo-EM Centers) - Submit an eligibility form detailing current/planned capabilities, instrument time management, and a brief description of the research program enabled by the new instrumentation - Multiple proposals from the same institution are allowed, provided there is no overlap in research groups or infrastructure --- ## Application Process - Step 1: Complete and submit the eligibility form via the [online portal](https://beckman-foundation.smapply.io/) by February 26, 2021 - The Foundation reviews eligibility forms on a rolling basis; eligible applicants receive access to the full proposal portal no later than March 5, 2021 - Step 2: Eligible applicants submit a full proposal by June 11, 2021 - The full proposal must address: - The complete imaging workflow and justification for requested equipment - Any technology development, including engineering and risk mitigation plans - Data storage, analysis, and sharing strategies - Integration and training of junior scientists and interdisciplinary teams - Institutional support for the proposed project - Applications are reviewed by a scientific committee; feedback on unsuccessful proposals is not provided --- ## Additional Information - This was a one-time grant opportunity; the program is now closed for new applications. - Award announcements were anticipated in late 2021, and grants began in 2022. - Recent awardees and teams are listed on the [program recipients page](https://www.beckman-foundation.org/awarded-scientists/?award_program=FIB-Milling%20for%20Cellular%20CryoET). --- ## External Links - [Program Overview and RFP](https://www.beckman-foundation.org/programs/fib-milling-sample-preparation-cellular-cryoet/) - [Full Request for Proposals (PDF)](https://www.beckman-foundation.org/documents/90/FIB_Milling_Cryo-ET_RFP_Final.pdf) - [Online Application Portal](https://beckman-foundation.smapply.io/) - [Recent Recipients](https://www.beckman-foundation.org/awarded-scientists/?award_program=FIB-Milling%20for%20Cellular%20CryoET) - [Beckman Foundation Grant Programs](https://www.beckman-foundation.org/programs/) --- ## Contact Information | Contact | Email | Phone | Webpage | |---------------------------|-----------------------------------------------|-----------------|----------------------------------------------------------------| | Anne Hultgren (Program) | InstrumentGrants@beckman-foundation.org | +1 949-531-0400 | [Contact Page](https://www.beckman-foundation.org/contacts/) |

FIB-Milling Sample Preparation for Cellular CryoET

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