[Crohn's and Colitis Foundation](https://www.crohnscolitisfoundation.org)

March 30, 2023 (Letter of Intent) | July 24, 2023 (Full proposal)

Up to $900,000 over 3 years; initial $450,000 for 1.5 years, with continued funding contingent on progress.

Supports research on the biological mechanisms and potential treatments for fibrosis in Crohn's disease and ulcerative colitis.

--- ## Description This initiative funds research projects investigating the biological mechanisms underlying fibrosis in inflammatory bowel disease (IBD), specifically Crohn’s disease and ulcerative colitis. The program aims to advance understanding of fibrotic complications, identify patient subgroups through multi-omics analysis, evaluate new therapeutic strategies, and promote multidisciplinary research approaches. Projects should be based on clinical observations or published human data and are expected to contribute to prevention or treatment strategies for IBD-associated fibrosis beyond surgical intervention. --- ## Due Dates - Letter of Intent (LOI) application deadline: March 30, 2023 - Full proposal submission deadline: July 24, 2023 --- ## Funding Amount - Maximum award: Up to $900,000 total over 3 years - Initial funding: $450,000 for 1.5 years - Continued funding for an additional 1.5 years ($450,000) is contingent on exceptional progress toward milestones - Maximum annual budget: $300,000 per year (inclusive of up to 10% indirect costs) - Up to two projects may be funded --- ## Eligibility - Applications must be submitted by a research team with: - One lead Principal Investigator (PI): senior faculty (Professor, Head of Research, Associate Professor) with expertise in fibrosis (preferably in IBD, but other areas considered if paired with IBD expertise) - At least one junior Co-PI: Instructor or Assistant Professor (prior to independent R01 grant or equivalent), with experience in IBD research and within 10 years of doctoral degree - Additional co-investigators are encouraged, especially those with complementary expertise - Both U.S. and international applicants are eligible; no geographic restrictions - Eligible institutions: public or private non-profits engaged in health care or health-related research; collaborations with for-profit subcontractors (e.g., CROs) are allowed - Applications from diverse teams, including underrepresented groups, are strongly encouraged --- ## Application Process 1. **Letter of Intent (LOI):** - Submit via [ProposalCENTRAL](https://proposalcentral.com/) - LOIs are competitively evaluated for alignment with program scope and feasibility - Only selected LOIs are invited for full proposal submission 2. **Full Proposal:** - Invited applicants submit a comprehensive research plan, budget, biosketches, and supporting documents through ProposalCENTRAL - Proposals are peer reviewed for scientific merit, translational potential, and team qualifications 3. **Required Documents:** - NIH-format biosketches for key personnel - Budget and justification - Research plan (maximum 10 pages) - Letters of collaboration (if applicable) - Institutional approvals for human/animal research (prior to award start) 4. **Reporting:** - Progress reports every six months - Annual oversight meetings and presentations For detailed instructions, refer to the [program RFP and guidelines (PDF)](https://www.crohnscolitisfoundation.org/sites/default/files/2023-06/2023-May-2-Fibrosis%20in%20IBD%20RFP%20Updated.pdf). --- ## Additional Information - Awardees must comply with Crohn’s & Colitis Foundation and Takeda Alliance terms, including IP reporting and publication review. - Travel to annual oversight meetings in New York (December) should be included in the budget. - Indirect costs are capped at 10%. - Intellectual property developed may be subject to collaborative agreements with Takeda; see RFP for details. --- ## External Links - [Program Overview and Application Guidelines (PDF)](https://www.crohnscolitisfoundation.org/sites/default/files/2023-06/2023-May-2-Fibrosis%20in%20IBD%20RFP%20Updated.pdf) - [Fibrosis in IBD Research Initiative Program Page](https://www.crohnscolitisfoundation.org/research/grants-fellowships/fibrosis-ibd-research-initiative) - [ProposalCENTRAL Application Portal](https://proposalcentral.com/) - [Crohn's & Colitis Foundation Research Funding Opportunities](https://www.crohnscolitisfoundation.org/research/grants-fellowships) - [Foundation Post-Award Policies](https://www.crohnscolitisfoundation.org/research/post-award-policies) --- ## Contact Information | Name/Role | Email | Phone | Web Contact | |---------------------------------------------|-----------------------------------------------------|--------------------|------------------------------------------------------------------------------------------------------| | Research Program (General Inquiries) | [ibdfibrosis@crohnscolitisfoundation.org](mailto:ibdfibrosis@crohnscolitisfoundation.org) | +1 800-932-2423 | [Contact Form](https://www.crohnscolitisfoundation.org/contact) | | Dr. Andrés Hurtado-Lorenzo, VP, Translational Research & IBD Ventures | [ibdfibrosis@crohnscolitisfoundation.org](mailto:ibdfibrosis@crohnscolitisfoundation.org) | | | | Dr. Ji-eun Oh, Senior Manager, Translational Research | [ibdfibrosis@crohnscolitisfoundation.org](mailto:ibdfibrosis@crohnscolitisfoundation.org) | | |

Fibrosis in IBD Research Initiative - Crohn's and Colitis Foundation

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