[Crohn's and Colitis Foundation](https://www.crohnscolitisfoundation.org)

Closed (LOI: March 30, 2023 | Full Proposal: July 24, 2023)

Up to $900,000 total over 3 years; initial $450,000 for 1.5 years, with renewal contingent on progress.

Supports research into the mechanisms and therapeutic targets of fibrosis in IBD, emphasizing translational and multidisciplinary approaches.

Requires a team with both a senior PI and a junior Co-PI; open to US and international applicants.

--- ## Description The Crohn's & Colitis Foundation, in collaboration with Takeda, seeks to fund innovative research projects investigating the biological mechanisms underlying fibrosis in inflammatory bowel disease (IBD), including both Crohn’s Disease and ulcerative colitis. The initiative aims to address the unmet need for understanding, preventing, and treating fibrotic complications in IBD, which currently lack effective non-surgical solutions. Research should build upon clinical observations or published human IBD data, with particular interest in translational and multidisciplinary studies. Areas of focus include: - Pathophysiology of fibrosis and patient segmentation/endotyping (especially via multi-omics analysis) - Use of datasets and biosamples from demographically and ethnically diverse cohorts - Evaluation of the therapeutic potential of targeting fibrotic pathways - Cellular mechanisms of fibrosis - Role of the microbiome in fibrosis - Multidisciplinary approaches spanning basic, translational, and clinical research --- ## Due Dates - Letter of Intent (LOI) deadline: March 30, 2023 - Full proposal deadline (by invitation): July 24, 2023 *This cycle is now closed; check the [program page](https://www.crohnscolitisfoundation.org/research/grants-fellowships/fibrosis-ibd-research-initiative) for future opportunities or updates.* --- ## Funding Amount - Up to $900,000 total per award over three years - $450,000 for the first 1.5 years - Renewal for an additional 1.5 years (up to $450,000) contingent on exceptional progress toward specified milestones --- ## Eligibility - Applications must be submitted by teams with complementary expertise in IBD and fibrosis. - Teams must include: - One lead Principal Investigator (PI): Professor, Head of Research, or Associate Professor - At least one junior Co-PI: Instructor or Assistant Professor - Open to both US-based and international researchers. - Multidisciplinary and collaborative teams are strongly encouraged. --- ## Application Process 1. **Letter of Intent (LOI):** - Submit via [ProposalCENTRAL](https://proposalcentral.com/) - Only selected LOIs will be invited for full proposal submission. 2. **Full Proposal:** - Invited teams will be asked to submit detailed proposals. - Application guidelines and RFP details are available in the [program overview PDF](https://www.crohnscolitisfoundation.org/sites/default/files/2023-06/2023-May-2-Fibrosis%20in%20IBD%20RFP%20Updated.pdf). 3. **Review Process:** - Proposals are evaluated for scientific merit, innovation, and relevance to the Foundation’s mission. - Progress in the first 1.5 years is required for renewal. --- ## Additional Information - Projects leveraging diverse patient cohorts, advanced omics, and translational approaches are prioritized. - The initiative encourages the use of existing clinical datasets and biosamples. - Multidisciplinary collaboration across institutions and specialties is highly valued. --- ## External Links - [Program Overview & Guidelines (PDF)](https://www.crohnscolitisfoundation.org/sites/default/files/2023-06/2023-May-2-Fibrosis%20in%20IBD%20RFP%20Updated.pdf) - [Program Page](https://www.crohnscolitisfoundation.org/research/grants-fellowships/fibrosis-ibd-research-initiative) - [Apply via ProposalCENTRAL](https://proposalcentral.com/) - [All Crohn's & Colitis Foundation Research Opportunities](https://www.crohnscolitisfoundation.org/research/grants-fellowships) --- ## Contact Information | Purpose | Contact | |---------------------|------------------------------------------| | General Inquiries | [ibdfibrosis@crohnscolitisfoundation.org](mailto:ibdfibrosis@crohnscolitisfoundation.org) | | Foundation Info | [info@crohnscolitisfoundation.org](mailto:info@crohnscolitisfoundation.org) | | Phone | +1 800-932-2423 | | Contact Page | [Contact Form](https://www.crohnscolitisfoundation.org/contact) |

Fibrosis in IBD Research Initiative

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