The Department of Energy Office of Science is accepting research proposals in multiple scientific fields for financial assistance through September 30, 2026.
Funder: Office of Science
Due Dates: September 30, 2026 (Full applications) | Target dates for subprograms: October 31, 2025 (Pre-apps—Electron & Scanning Probe); November 14, 2025 (Pre-apps—Inverse Methods/Quantum Computing); November 30, 2025 (Pre-apps—BES core); December 31, 2025 (Full—Electron & Scanning Probe); February 1, 2026 (Full—BES core); January 16 & 28, 2026 (Full—ASCR panels)
Funding Amounts: $50,000–$5,000,000 per award; most project periods 3 years; up to $500M total program funding; ~200–350 new awards/year.
Summary: Annual open call for basic research proposals in all DOE Office of Science mission areas, including computing, energy, materials, environment, physics, and isotope R&D.
Key Information: Unrestricted eligibility (except DOE/NNSA labs as lead); pre-applications encouraged; multiple topic-specific deadlines apply.
This annual, open Notice of Funding Opportunity (NOFO) from the U.S. Department of Energy (DOE) Office of Science supports basic research across all Office of Science (SC) program areas. The solicitation welcomes proposals in Advanced Scientific Computing Research, Basic Energy Sciences, Biological and Environmental Research, Fusion Energy Sciences, High Energy Physics, Nuclear Physics, and Isotope R&D and Production. Proposals must align with the SC’s Congressionally authorized mission and advance fundamental scientific understanding rather than address commercial applications. The NOFO remains open throughout the fiscal year, with topic-specific review cycles and target dates for pre-applications and full proposals.