Atom | Stimulating Hematology Investigation: New Endeavors (SHINE) (R01 Clinical Trial Not Allowed)

Funder: National Institutes of Health

Due Dates: June 5, 2025 (New R01) | July 5, 2025 (Renewal/Resubmission/Revision) | October 5, 2025 (New R01) | November 5, 2025 (Renewal/Resubmission/Revision) | Additional standard NIH R01 dates through January 2028

Funding Amounts: Estimated 5–8 awards; total of $2.5M in FY25; budgets not limited but must reflect actual needs; max project period 5 years.

Summary: Supports innovative, high-quality nonmalignant hematology research in basic and early translational science aligned with NIDDK, NIA, and NHLBI missions; clinical trials are not allowed.

Key Information: Applicants requesting ≥$500,000 direct costs in any year must contact a program officer at least 6 weeks before submission.

Description

The SHINE program is designed to catalyze innovative research in nonmalignant hematology, focusing on basic and early translational science relevant to the missions of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute on Aging (NIA), and National Heart, Lung, and Blood Institute (NHLBI). The program aims to:

Advance understanding of the pathogenesis, prevention, detection, and potential treatment of nonmalignant hematologic diseases.
Attract new investigators to the field.
Promote interdisciplinary collaborations.
Support timely, high-impact, and leading-edge research.

Research topics supported by SHINE are updated regularly to reflect emerging priorities. Current areas of interest include:

Metabolic modulators of hematopoiesis
Remodeling the hematopoietic stem cell niche
Biology of erythrocyte maturation
Hematopoietic response to stress
Modeling the bone marrow microenvironment after conditioning or in nonmalignant hematologic diseases

Applicants are encouraged to review the current list of SHINE topics and contact NIH program staff to discuss project fit.

Note: Clinical trials are not allowed under this funding opportunity.

Due Dates

New R01 Applications: June 5, 2025 | October 5, 2025 | February 5, 2026 | June 5, 2026 | October 5, 2026 | February 5, 2027 | June 5, 2027 | October 5, 2027
Renewal, Resubmission, or Revision R01 Applications: July 5, 2025 | November 5, 2025 | March 5, 2026 | July 5, 2026 | November 5, 2026 | March 5, 2027 | July 5, 2027 | November 5, 2027

All applications are due by 5:00 PM local time of the applicant organization. The final closing date for this opportunity is January 6, 2028.

Funding Amount

Estimated Number of Awards: 5–8 (beyond regular R01 funding)
Total Funding: $2,500,000 in FY25 (future years depend on appropriations)
Budget: No set limit; budgets must reflect actual project needs
Project Period: Up to 5 years

Applicants requesting $500,000 or more in direct costs in any year must contact a program officer at least 6 weeks before submission.

Eligibility

Eligible applicants include:

Public and private institutions of higher education
Nonprofits with or without 501(c)(3) status (other than institutions of higher education)
For-profit organizations (including small businesses)
State, county, city, township, and special district governments
Native American tribal governments and organizations
Independent school districts
Public housing authorities/Indian housing authorities
Faith-based and community-based organizations
Regional organizations
U.S. territories and possessions
Eligible agencies of the federal government

Not eligible: Non-U.S. (foreign) organizations and non-U.S. components of U.S. organizations. However, foreign components as defined in the NIH Grants Policy Statement are allowed.

Any individual with the skills, knowledge, and resources necessary to carry out the proposed research may apply as PD/PI.

Application Process

Submission: Applications must be submitted electronically via NIH ASSIST, Grants.gov Workspace, or an institutional system-to-system solution.
Instructions: Follow the NIH How to Apply - Application Guide and all program-specific instructions in the NOFO.
Registrations Required: SAM, eRA Commons, Grants.gov (can take 6+ weeks).
Page Limits: Standard NIH R01 page limits apply.
Data Management: All applications must include a Data Management and Sharing Plan.
Large Budgets: Applicants requesting $500,000 or more in direct costs in any year must contact a program officer at least 6 weeks before submission.

Additional Information

Review Criteria: Significance, innovation, approach (rigor and feasibility), investigator(s), and environment.
No cost sharing required.
No clinical trials allowed.
Emerging topics: SHINE research priorities are updated regularly; applicants should check the NOFO page for the latest topics.
Workshops: SHINE topics are informed by NIH workshops and public meetings; researchers are encouraged to participate.

External Links

Contact Information

Contact Type	Name/Institute	Email	Phone
Scientific/Research	Shilpa Hattangadi, M.D. (NIDDK)	shilpam.hattangadi@nih.gov	301-594-7726
Scientific/Research	Cindy N. Roy, Ph.D. (NIDDK)	cindy.roy@nih.gov	301-594-8805
Scientific/Research	Brian Bai, Ph.D. (NHLBI)	brian.bai@nih.gov	301-435-0080
Scientific/Research	John P. Williams, Ph.D. (NIA)	williamsj6@mail.nih.gov	301-496-6403
Grants Management	Diana Ly (NIDDK)	dianaly@mail.nih.gov	301-594-9249
Grants Management	Shaheed Michael Ziyout (NHLBI)	shaheed.ziyout@nih.gov	301-827-8152
Grants Management	Jessica Perez (NIA)	perezj@mail.nih.gov	301-496-1472
General Grants Info	NIH Grants Info	GrantsInfo@nih.gov	301-480-7075
Application Support	eRA Service Desk	eRA Help	301-402-7469 / 866-504-9552
Grants.gov Support	Grants.gov	support@grants.gov	800-518-4726