Stimulating Hematology Investigation: New Endeavors (SHINE) (R01 Clinical Trial Not Allowed)
Funding for nonmalignant hematology research available through the SHINE program to support innovative projects in collaboration with NIDDK, NIA, and NHLBI.
Funder: National Institutes of Health
Due Dates: June 5, 2025 (New R01) | July 5, 2025 (Renewal/Resubmission/Revision) | October 5, 2025 (New R01) | November 5, 2025 (Renewal/Resubmission/Revision) | Additional standard NIH R01 dates through January 2028
Funding Amounts: Estimated 5–8 awards; total of $2.5M in FY25; budgets not limited but must reflect actual needs; max project period 5 years.
Summary: Supports innovative, high-quality nonmalignant hematology research in basic and early translational science aligned with NIDDK, NIA, and NHLBI missions; clinical trials are not allowed.
Key Information: Applicants requesting ≥$500,000 direct costs in any year must contact a program officer at least 6 weeks before submission.
Description
The SHINE program is designed to catalyze innovative research in nonmalignant hematology, focusing on basic and early translational science relevant to the missions of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute on Aging (NIA), and National Heart, Lung, and Blood Institute (NHLBI). The program aims to:
- Advance understanding of the pathogenesis, prevention, detection, and potential treatment of nonmalignant hematologic diseases.
- Attract new investigators to the field.
- Promote interdisciplinary collaborations.
- Support timely, high-impact, and leading-edge research.
Research topics supported by SHINE are updated regularly to reflect emerging priorities. Current areas of interest include:
- Metabolic modulators of hematopoiesis
- Remodeling the hematopoietic stem cell niche
- Biology of erythrocyte maturation
- Hematopoietic response to stress
- Modeling the bone marrow microenvironment after conditioning or in nonmalignant hematologic diseases
Applicants are encouraged to review the current list of SHINE topics and contact NIH program staff to discuss project fit.
Note: Clinical trials are not allowed under this funding opportunity.
