Illuminating AD/ADRD Genome to Enable Precision Genomic Medicine
This grant will fund interdisciplinary research using advanced genomic and analytical tools to uncover genetic mechanisms of Alzheimer's and related dementias, aiming to identify new precision medicine targets.
Funder: National Institutes of Health (NIH)
Due Dates: October 6, 2026 (Estimated, forecasted opportunity)
Funding Amounts: Not yet specified; details to be announced in the official NOFO
Summary: Supports integrative, cross-disciplinary research to elucidate the genomic mechanisms underlying Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias (AD/ADRD) and enable precision genomic medicine approaches.
Key Information: This is a forecasted opportunity; applications are not yet being solicited.
Description
The National Institute on Aging (NIA), part of the NIH, intends to issue a Notice of Funding Opportunity (NOFO) to support integrative, cross-disciplinary research aimed at scaling up mechanistic studies to understand the genomic underpinnings of the pathogenesis and progression of Alzheimer’s Disease (AD) and Alzheimer’s Disease-Related Dementias (ADRD).
Projects funded under this future opportunity are expected to:
- Employ interdisciplinary approaches that integrate innovative techniques to dissect the genomic drivers of AD/ADRD.
- Leverage advanced analytical methods such as machine learning, comparative genomic analysis across multiple genetic ancestries or neurodegenerative diseases, genome editing, functional characterization assays, and emerging single-cell and spatial omics technologies.
- Utilize sophisticated disease models, including human stem cell-based systems, ex vivo and in vivo models, reflecting diverse genetic ancestries, various model organisms, or multiple neurodegenerative conditions.
- Enable comprehensive investigation of genomic drivers of neurodegeneration and neuropathogenesis, with the ultimate goal of identifying actionable therapeutic targets and informing mechanism-driven precision medicine approaches for AD/ADRD.
This is a forecasted opportunity, intended to provide potential applicants with sufficient time to develop collaborations and responsive projects. The formal NOFO will use the U01 Cooperative Agreement mechanism.
