[National Institutes of Health](https://www.nih.gov)

June 4, 2026 (Full application)

Up to $3,000,000 per award; estimated total program funding $9,600,000; ~3 awards expected

Supports research on how initial and repeated influenza exposures or vaccinations shape infant and childhood immunity to inform future vaccine design.

Foreign subawards/subcontracts are not allowed; see eligibility for international collaboration rules.

--- ## Description This opportunity supports the establishment or continuation of longitudinal infant cohorts to determine and compare how initial and repeated natural influenza infections and/or influenza vaccinations shape infant and childhood immunity to future influenza exposures. The primary goal is to understand how these exposures influence immune responses to subsequent influenza infections and/or vaccines, ultimately providing key information to facilitate the design of durable, broadly protective influenza vaccines. --- ## Due Dates - June 4, 2026: Full application (current closing date) --- ## Funding Amount - Maximum award ceiling: $3,000,000 per project - Estimated total program funding: $9,600,000 - Expected number of awards: 3 - No cost sharing or matching required --- ## Eligibility - Eligible applicants include: - State, county, city, or township governments - Special district governments - Independent school districts - Public and state-controlled institutions of higher education - Native American tribal governments (federally recognized and other) - Public housing authorities/Indian housing authorities - Nonprofits (with or without 501(c)(3) status, excluding institutions of higher education) - Private institutions of higher education - For-profit organizations (including small businesses) - Others as specified in the NOFO - Non-domestic (non-U.S.) entities and non-domestic components of U.S. organizations are eligible. - Foreign components, as defined in the NIH Grants Policy Statement, are allowed. - **Important:** NIH will not fund applications that include foreign subawards/subcontracts under this NOFO. Only unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors are permitted. --- ## Application Process - Applications must be submitted via [Grants.gov](https://www.grants.gov/search-results-detail/359939). - Carefully review the full Notice of Funding Opportunity (NOFO) for detailed requirements and instructions. - Refer to Section III of the NOFO for comprehensive eligibility information. - Ensure compliance with NIH policies on foreign collaborations and subawards. --- ## Additional Information - This is a Cooperative Agreement (U01); clinical trials are not allowed. - The program falls under the category of Health, specifically Allergy and Infectious Diseases Research (Assistance Listing 93.855). - For further clarification or technical questions, contact the NIH program email below. --- ## External Links - [NIH Funder Home Page](https://www.nih.gov) - [Official Grants.gov Opportunity Listing](https://www.grants.gov/search-results-detail/359939) - [Apply via Grants.gov](https://apply07.grants.gov/apply/jsf/workspace/createWorkspace.faces?activityID=CreateWorkspace&cleanSession=1&oppId=359939) --- ## Contact Information | Purpose | Contact | |------------------------|-----------------------------------------| | General inquiries | [imprintingNOFO@mail.nih.gov](mailto:imprintingNOFO@mail.nih.gov) | | NIH main phone | 301-496-4000 |

Impact of Initial Influenza Exposure on Immunity in Infants

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