Funder: Patient-Centered Outcomes Research Institute (PCORI)
Due Dates: May 13, 2025 (LOI) | September 3, 2025 (Full Application)
Funding Amounts: Up to $750,000 total direct costs over up to 3 years; $12 million available for this cycle.
Summary: Supports research to address high-priority methodological gaps in patient-centered comparative clinical effectiveness research (CER), with a focus on AI/ML, study design, data networks, and ethics.
Key Information: Letter of Intent required; addressing one of four program priorities is mandatory for responsiveness.
This funding opportunity from PCORI seeks to advance the methods used in patient-centered comparative clinical effectiveness research (CER). The focus is on closing high-priority methodological gaps that, if addressed, will improve the strength and quality of evidence generated by CER studies. For the 2025 Cycle 2 competition, PCORI is particularly interested in proposals that develop or improve methods in the following areas:
Applicants are encouraged, but not required, to address PCORI’s evolving Research Project Agenda Topic Themes. However, proposals must address at least one of the four specified program priorities to be considered responsive.
PCORI emphasizes meaningful engagement of patients and stakeholders in research. All applicants are expected to address PCORI’s Foundational Expectations for Partnerships in Research, with flexibility for highly technical projects.
Eligible applicants include:
There are no restrictions on citizenship or geographic location, but projects must be relevant to patient-centered CER.
For detailed guidance, see the full announcement PDF.
| Contact Type | Details |
|---|---|
| General Inquiries | info@pcori.org |
| Program Questions | pfa@pcori.org |
| Phone | (202) 827-7700 |
| Contact Form | PCORI Contact Page |