Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research PCORI Funding Announcement -- Cycle 3 2026
Supports research to improve methods in patient-centered comparative effectiveness studies, focusing on measurement, real-world data, AI, and study design.
Funder: Patient-Centered Outcomes Research Institute
Due Dates: September 9, 2026 (LOI) | January 12, 2027 (Full application)
Funding Amounts: Up to $750,000 direct costs per project; maximum project period up to three years.
Summary: Supports research to improve methods in patient-centered comparative clinical effectiveness studies, focusing on measurement, real-world data, AI, and study design.
Key Information: Applicants must address PCORI’s Foundational Expectations for Partnerships in Research in their engagement plans.
Description
This funding opportunity supports research that addresses high-impact methodological gaps in patient-centered comparative clinical effectiveness research (CER). The goal is to enhance the strength and quality of evidence generated by CER studies through advancements in methods related to:
- Patient-centered measurement
- Use of real-world data in multi-site CER
- Artificial intelligence and machine learning applications in CER
- Study design improvements
Projects should focus on developing innovative methodologies that make CER more relevant and useful for healthcare decision-making. A key requirement is the meaningful engagement of patients and stakeholders throughout the research process, in line with PCORI’s Foundational Expectations for Partnerships in Research.
