Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research PCORI Funding Announcement -- Cycle 2 2026
Forecasted
PCORI funds research to advance methods for patient-centered comparative clinical effectiveness research, focusing on measurement, real-world data, AI/ML, and innovative study design.
Funder: Patient-Centered Outcomes Research Institute
Due Dates (Anticipated): April 2027 (LOI) | September 2027 (Application)
Funding Amounts: Up to $750,000 direct costs per project (max 3 years); total cycle funding ~$12 million
Summary: Supports methodological research to advance patient-centered comparative clinical effectiveness research (CER), emphasizing measurement, real-world data, AI/ML, and study design innovation.
Key Information: These are projected dates based on the annual cycle; confirm on the program page before applying.
Description
This opportunity from the Patient-Centered Outcomes Research Institute (PCORI) funds research to improve methods for conducting patient-centered comparative clinical effectiveness research (CER). The program seeks innovative proposals that address high-priority methodological gaps in CER, with a focus on advancing patient-centered measurement, integrating real-world data, leveraging artificial intelligence and machine learning, and improving study design. Projects must emphasize meaningful patient and stakeholder engagement throughout the research process and are encouraged to utilize open science resources such as the Patient-Centered Outcomes Data Repository (PCODR). The overarching goal is to strengthen the quality, relevance, and impact of CER to better inform healthcare decision-making.
