Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research PCORI Funding Announcement - Cycle 2 2026
Forecasted
Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research supports researchers developing and refining methods to strengthen evidence for healthcare decisions.
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Funder: Patient-Centered Outcomes Research Institute
Due Dates (Anticipated): April 2027 (LOI) | September 2027 (Application)
Funding Amounts: Up to $750,000 in direct costs for up to three years; approximately $12 million available
Summary: Supports methodological research that improves the strength and quality of evidence from patient-centered comparative clinical effectiveness research.
Key Information: Each PI or Dual-PI may submit only one LOI per cycle across applicable PCORI funding announcements.
Description
PCORI’s Methods funding announcement supports research addressing high-priority methodological gaps in patient-centered comparative clinical effectiveness research (CER). Projects may develop new methods or evaluate, compare and refine existing approaches, with an emphasis on bridging methodological innovation and practical application. The goal is stronger, more useful evidence for healthcare decisions, rather than funding clinical effectiveness studies themselves.
The program has four priorities: patient-centered measurement, real-world data in multi-site CER, artificial intelligence and machine learning, and study design. Topics include measurement harmonization, patient-centered burdens and economic outcomes, synthetic data, digital health outcome measurement, and AI-supported research processes and health communication. Ethical and human subjects protections issues cut across these priorities. Patients and other research partners are expected to contribute relevant lived experience or professional expertise.
