Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research PCORI Funding Announcement -- Cycle 2 2026
PCORI's 2026 grant supports research to improve methods in patient-centered comparative clinical effectiveness studies, focusing on measurement, real-world data, AI/ML, and study design.
Funder: Patient-Centered Outcomes Research Institute
Due Dates: April 28, 2026 (Letter of Intent) | September 1, 2026 (Full application)
Funding Amounts: Up to $750,000 direct costs per project; project period up to 3 years; total cycle funding up to $12 million.
Summary: Supports research to advance methods in patient-centered comparative clinical effectiveness research, with priorities in measurement, real-world data, AI/ML, and study design.
Key Information: LOI is required and only invited applicants may submit a full application; strict PI/LOI submission limits apply.
Description
This Patient-Centered Outcomes Research Institute (PCORI) funding opportunity supports studies that address critical methodological gaps in patient-centered comparative clinical effectiveness research (CER). The program seeks to develop and enhance methods in four priority areas:
- Patient-centered measurement
- Use of real-world data (RWD) in multi-site CER
- Integration and evaluation of artificial intelligence (AI) and machine learning (ML) in CER
- Improvement of study design for CER
The goal is to strengthen the validity, reliability, and relevance of evidence generated from CER studies, ultimately enabling more effective and patient-relevant healthcare decision making.
