Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research PCORI Funding Announcement -- Cycle 2 2026
This grant funds research to improve methods for patient-centered comparative clinical effectiveness research, focusing on measurement, real-world data, AI/ML, and innovative study design.
Funder: Patient-Centered Outcomes Research Institute
Due Dates: April 28, 2026 (Letter of Intent, 5 pm ET) | September 1, 2026 (Full Application, 5 pm ET)
Funding Amounts: Up to $750,000 direct costs per award, project period up to 3 years; PCORI expects to commit up to $12 million total.
Summary: Supports research to advance methods for patient-centered comparative clinical effectiveness research, focusing on measurement, real-world data, artificial intelligence/machine learning, and study design.
Key Information: LOI required; only invited applicants can submit full applications; individuals may not apply.
Description
This opportunity funds studies that address high-priority methodological gaps in patient-centered comparative clinical effectiveness research (CER). Priority areas include developing and validating patient-centered measurement methods, enhancing the use of real-world data (RWD) in multi-site CER, improving the integration and application of artificial intelligence and machine learning (AI/ML) in CER, and advancing innovative study design methodologies. New priorities for this cycle include standardized approaches for measuring patient-centered burdens and economic outcomes, harmonizing data from diverse instruments, and leveraging synthetic data and digital health technologies. Projects must meaningfully engage patients and research partners to ensure relevance and utility for healthcare decision-making. Use of datasets from the Patient-Centered Outcomes Data Repository (PCODR) is encouraged but not required.
