Funder: Patient-Centered Outcomes Research Institute
Due Dates (Anticipated): April 2027 (LOI) | September 2027 (Application)
Funding Amounts: Up to $750,000 in direct costs for up to three years; approximately $12 million available
Summary: Supports methodological research that improves the quality and usefulness of patient-centered comparative clinical effectiveness research.
Key Information: Organizations may apply, but individuals cannot; full applications require an invitation following LOI review.
Description
The Patient-Centered Outcomes Research Institute (PCORI) supports studies addressing high-priority methodological gaps in patient-centered comparative clinical effectiveness research (CER). Projects may develop new methods or evaluate, compare and refine existing methods to strengthen evidence for healthcare decisions. The program encourages work connecting methodological innovation with practical application.
Four priorities cover patient-centered measurement, real-world data in multi-site CER, artificial intelligence and machine learning, and study design. Interests include measuring patient-centered burdens and economic outcomes, harmonizing measurement instruments, synthetic data, digital health outcome measurement, and AI-supported research processes and health communication. Ethical and human subjects protections issues span these priorities. Patients and other research partners are expected to contribute expertise that makes the research relevant and useful.
