INCLUDE Project: Clinical Trials Phased Awards for Down syndrome Research (R61/R33 Clinical Trial Required)
This NIH grant funds phased clinical trials to develop treatments for critical and co-occurring health conditions in people with Down syndrome, with milestone-driven research over up to five years.
Funder: National Institutes of Health
Due Dates (Anticipated): February 2027 (full application, projected) | February 2026 (projected)
Funding Amounts: Estimated total program funding: $3,000,000; Award floor: $100,000; Up to 5 years per project (2 years R61, up to 3 years R33)
Summary: Supports milestone-driven clinical trials to address critical and co-occurring health conditions in individuals with Down syndrome.
Description
The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project funds phased (R61/R33) clinical trials aimed at improving health and quality of life for individuals with Down syndrome. This opportunity supports exploratory and developmental studies (R61 phase, up to 2 years) that, upon achieving specific milestones, may transition to full clinical trial support (R33 phase, up to 3 years). The focus is on developing interventions for critical and co-occurring health conditions in this population, with a total project duration not to exceed five years. All projects must be milestone-driven.
