[Bill and Melinda Gates Foundation](https://www.gatesfoundation.org)

March 25, 2025: Full application deadline

Up to $500,000 USD per project for up to 2 years; indirect costs included within this limit, per Gates Foundation policy.

Supports innovative research for early detection, prevention, and treatment of preeclampsia with a focus on scalable solutions for low- and middle-income countries.

--- ## Description This opportunity seeks proposals for innovative solutions to reduce the global burden of preeclampsia—a leading cause of maternal and neonatal morbidity and mortality. The funder aims to support projects that advance early detection (including novel biomarkers and diagnostics), deepen understanding of disease mechanisms and heterogeneity, and develop preventive or therapeutic interventions. Projects must be adaptable and scalable for low- and middle-income countries (LMICs) and are encouraged to leverage cross-sector collaborations, although collaboration is not required. --- ## Due Dates - March 25, 2025: Full application deadline (applications due by 11:30 a.m. U.S. Pacific Time) --- ## Funding Amount - Maximum award: Up to $500,000 USD per project - Project duration: Up to 2 years - Indirect costs: Included within the $500,000 cap, subject to the [Gates Foundation's indirect cost policy](https://docs.gatesfoundation.org/Documents/Indirect_Cost_Policy.pdf) - Budgets should be commensurate with the proposed scope of work --- ## Eligibility - Open to nonprofit organizations, for-profit companies, international organizations, government agencies, and academic institutions worldwide. - Especially encouraged: Projects led by women, women-led organizations, and applicants based in LMICs. - No specific PI qualifications required; must demonstrate capacity to carry out the work. - U.S. organizations are not required to partner with LMIC institutions, but LMIC relevance and patient inclusion are expected. - Multiple proposals allowed, but each must have a distinct PI and email address. - Awards are made to organizations, not individuals. --- ## Application Process - Applications must be submitted via the [Grand Challenges portal](https://gcgh.grandchallenges.org/challenge/reducing-burden-preeclampsia). - Required components: - Applicant profile (via portal) - Proposal (max 4 pages, including figures/references; Word or PDF) - Budget table and narrative (1 page, using provided template) - Adhere to formatting requirements (see [Application Instructions](https://gcgh.grandchallenges.org/sites/default/files/files/reducing_the_burden_of_preeclampsia_application_instructions.pdf)). - Proposals may be edited until the deadline. - Review the [Rules and Guidelines](https://gcgh.grandchallenges.org/sites/default/files/files/reducing_the_burden_of_preeclampsia_rules_and_guidelines.pdf) and [FAQs](https://gcgh.grandchallenges.org/reducing-burden-preeclampsia-frequently-asked-questions-faqs) before submitting. --- ## Additional Information ### Prioritized Research Areas - Early prediction and detection: Novel biomarkers, diagnostics, and point-of-care technologies. - Understanding pathophysiology: Mechanistic studies and disease heterogeneity. - Preventive/therapeutic interventions: New drugs, repurposed medications, or approaches synergistic with known therapies (e.g., low-dose aspirin). ### Not Funded - Implementation science or health systems integration projects. - Proposals lacking LMIC relevance or scalability. - Basic research without clear translational relevance. - Proposals without a clear, testable hypothesis. - Projects focused predominantly on postpartum interventions or awareness campaigns. ### Other Requirements - All information submitted is considered non-confidential. - Global Access policy applies: outcomes and products must be made available affordably in LMICs. - Indirect cost policy and grant terms apply as per Gates Foundation guidelines. --- ## External Links - [Challenge Details & Application Portal](https://gcgh.grandchallenges.org/challenge/reducing-burden-preeclampsia) - [Rules and Guidelines (PDF)](https://gcgh.grandchallenges.org/sites/default/files/files/reducing_the_burden_of_preeclampsia_rules_and_guidelines.pdf) - [Application Instructions (PDF)](https://gcgh.grandchallenges.org/sites/default/files/files/reducing_the_burden_of_preeclampsia_application_instructions.pdf) - [Frequently Asked Questions](https://gcgh.grandchallenges.org/reducing-burden-preeclampsia-frequently-asked-questions-faqs) - [Indirect Cost Policy](https://docs.gatesfoundation.org/Documents/Indirect_Cost_Policy.pdf) - [Gates Foundation Grant Opportunities](https://www.gatesfoundation.org/How-We-Work/General-Information/Grant-Opportunities) --- ## Contact Information | Purpose | Contact | |------------------------|--------------------------------------------| | General inquiries | [grandchallenges@gatesfoundation.org](mailto:grandchallenges@gatesfoundation.org) | | Funder website | [https://www.gatesfoundation.org/about/contact](https://www.gatesfoundation.org/about/contact) | | Phone | +1 206-709-3100 |

Reducing the Burden of Preeclampsia - Bill and Melinda Gates Foundation

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