Intervention Research to Improve Native American Health (R34 Clinical Trial Optional)
This grant funds research to develop, adapt, or test culturally appropriate health interventions aimed at reducing disease and improving health among Native American populations.
Funder: National Institutes of Health (NIH)
Due Dates: October 21, 2025 | October 21, 2026 | January 7, 2026 (AIDS) | January 7, 2027 (AIDS)
Funding Amounts: Up to $450,000 direct costs over 3 years; max $225,000 direct costs in any single year.
Summary: Supports planning, pilot, and feasibility research for interventions to improve health in Native American populations, emphasizing community engagement and cultural appropriateness.
Key Information: Community partnership and culturally grounded approaches are required; efficacy/effectiveness trials are not supported under this mechanism.
Description
This funding opportunity supports planning and development activities, including pilot or feasibility research, to improve health in Native American (NA) populations. The intent is to enable researchers and tribal/community partners to collaboratively develop, adapt, and test the feasibility or acceptability of interventions and research protocols before launching full-scale clinical trials. Projects should focus on health promotion, disease prevention, treatment, recovery, or services research that will inform future intervention implementation and dissemination.
Key emphases include:
- Active engagement and partnership with Native communities throughout the research process.
- Culturally grounded and community-informed study designs.
- Testing or adapting interventions for feasibility, acceptability, and sustainability.
- Building capacity for future efficacy, effectiveness, or implementation trials.
This opportunity is part of the Intervention Research to Improve Native American Health (IRINAH) initiative.
