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    Research, Development, and Training in Isotope Production

    The DOE seeks proposals for isotope R&D using AI/ML, advanced chemistry, and separation science, with a focus on training the next generation of experts.

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    This grant is no longer accepting proposals

    Office of Science has archived this opportunity.

    Funder: Office of Science

    Due Dates: February 17, 2025 (Pre-application) | February 28, 2025 (Pre-app response) | April 17, 2025 (Full application)

    Funding Amounts: Up to $750,000/year per award (2-year projects); total program funding up to $11M; 8–12 awards expected

    Summary: Supports research, development, and training in isotope production, with a focus on AI/ML, advanced chemistry, separation science, and workforce development.

    Key Information: Pre-application is required; eligibility limited to U.S. institutions of higher education, non-profits, and DOE/NNSA National Labs; for-profit entities may only participate as subrecipients.


    Description

    This opportunity from the U.S. Department of Energy (DOE) Office of Science funds research, development, and training projects in isotope production. The program is focused on advancing fundamental understanding and developing innovative, efficient technologies for enriching, producing, processing, recycling, and purifying radioactive and stable isotopes that are in short supply. The 2025 call is narrowly focused on:

    • Artificial intelligence and machine learning (AI/ML) applications
    • Enhanced processing chemistry, especially involving phase changes
    • Separation science

    A strong emphasis is placed on projects that incorporate effective training for the next generation of personnel in isotope production, processing, and purification. The program aims to support the U.S. scientific, technical, and economic strength by ensuring a robust domestic supply of critical isotopes for applications in medicine, national security, energy, advanced manufacturing, and more.


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