Neurobiology of Brain Disorders Award supports scientists applying basic neuroscience discoveries to neurological and psychiatric disorder mechanisms to advance diagnosis, prevention, and treatment.
Funder: McKnight Foundation
Due Dates: October 15, 2026, at 5 PM Central time (Application deadline)
Funding Amounts: Up to four awards of $300,000 each ($100,000 annually for three years)
Summary: Supports research applying basic neuroscience discoveries to mechanisms of human brain disorders and potential diagnostic or therapeutic advances.
Key Information: Applicants and all co-principal investigators must meet the independent-investigator and faculty-appointment eligibility requirements.
The Neurobiology of Brain Disorders Award is administered by the McKnight Endowment Fund for Neuroscience, an independent organization funded solely by the McKnight Foundation. It supports scientists applying basic research to neurological and psychiatric disorders, including mechanistic studies at the synaptic, cellular, molecular, genetic, or behavioral level. Research may involve humans or vertebrate and invertebrate model organisms. New approaches, potential paths toward therapeutic interventions, and collaborative or cross-disciplinary work are encouraged.
An additional priority is understanding environmental contributions to brain disorders, particularly early-life stress associated with later neurological and psychiatric conditions. Relevant influences include climate, nutrition, chemical exposure, pollution, family, education, housing, and poverty. The program recognizes communities of color’s higher exposure to these stressors and emphasizes equitable, inclusive laboratory environments.