Midcareer Investigator Award in Patient-Oriented Research (Parent K24 - Independent Basic Experimental Studies with Humans Required)

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Description

The NIH Midcareer Investigator Award in Patient-Oriented Research (K24) provides mid-career clinician-scientists with protected time to conduct patient-oriented research (POR) and to mentor junior clinical investigators. This specific opportunity is for independent basic experimental studies with humans—prospective studies that meet both the NIH definition of a clinical trial and of basic research. The award is designed to augment the research capabilities of established investigators and expand their role as mentors, thereby strengthening the pipeline of clinical researchers.

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Due Dates

• Standard NIH due dates apply for new, renewal, resubmission, and AIDS-related applications.
• Upcoming deadlines include:
  • June 12, 2024 (New)
  • July 12, 2024 (Renewal/Resubmission/Revision)
  • September 7, 2024 (AIDS)
  • October 12, 2024 (New)
  • November 12, 2024 (Renewal/Resubmission/Revision)
  • January 7, 2025 (AIDS)
  • Additional dates continue through May 7, 2027.
• All applications are due by 5:00 PM local time of the applicant organization.
• Full list of NIH standard due dates

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Funding Amount

• Salary Support: 3–6 person-months (25–50% full-time professional effort) per year, up to the NIH salary cap.
• Research Expenses: Up to $50,000 per year for research costs, including supplies, equipment, technical personnel, travel, and statistical services.
• Indirect Costs: 8% of modified total direct costs.
• Project Period: Up to 5 years; one-time renewal for an additional 3–5 years may be possible, subject to IC policy and continued eligibility.

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Eligibility

• Eligible Individuals:
  • Must have a health-professional doctoral degree (e.g., MD, DO, DDS, DMD, PharmD, PhD in clinical disciplines, etc.).
  • Typically at the Associate Professor level or equivalent.
  • Must have an established record of independent, peer-reviewed patient-oriented research funding and publications.
  • Must be a U.S. citizen, non-citizen national, or permanent resident by the time of award.
• Eligible Organizations:
  • U.S. higher education institutions (public/private)
  • Nonprofits (with or without 501(c)(3) status)
  • For-profit organizations (including small businesses)
  • State, local, and tribal governments
  • Independent school districts, public housing authorities, and certain other organizations
• Ineligible: Non-U.S. organizations and non-U.S. components of U.S. organizations (foreign components are allowed as defined by NIH policy).
• Other Requirements:
  • Must demonstrate the need for protected time (3–6 person-months) for research and mentoring.
  • Must have independent, peer-reviewed research support at the time of application and during the award.
  • Only one PD/PI per application; multiple PDs/PIs are not allowed.

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Application Process

• Application Submission: Electronic submission via NIH ASSIST, institutional system-to-system, or Grants.gov Workspace.
• Required Registrations: SAM, Grants.gov, eRA Commons, and ORCID for PD/PI.
• Application Components:
  • SF424 (R&R) forms
  • PHS 398 Career Development Award Supplemental Form (including candidate background, career goals, research plan, mentoring plan, institutional commitment)
  • Data Management and Sharing Plan
  • Human Subjects and Clinical Trials Information (must propose a basic experimental study with humans)
• Instructions: Follow the NIH Career Development (K) Application Guide and the specific funding announcement.
• Review: Applications are peer-reviewed for scientific merit, candidate qualifications, mentoring plan, research plan, and institutional environment.

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Additional Information

• Scope: Only applications proposing independent basic experimental studies with humans (NIH-defined clinical trials that are also basic research) are accepted under this announcement.
• Mentoring: A strong, detailed plan for mentoring junior clinical investigators is required.
• Institute/Center (IC) Participation: Not all NIH ICs participate; applicants must consult the Table of IC-Specific Information, Requirements, and Staff Contacts to ensure alignment with IC priorities and requirements.
• Renewal: One-time renewal may be possible if eligibility is maintained.
• Protected Time: The award is intended to relieve recipients from clinical and administrative duties to focus on research and mentoring.

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External Links

• NIH Funding Opportunity Announcement (PA-24-189)
• Table of IC-Specific Information, Requirements, and Staff Contacts
• NIH Career Development (K) Application Guide
• NIH Salary Cap Information
• NIH Grants Policy Statement
• Apply via Grants.gov

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Contact Information

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