[National Institutes of Health](https://www.nih.gov/)

November 17, 2025

Not specified; award amounts and duration vary by project

Supports small businesses developing automated, miniaturized tissue chip systems to advance biomedical research and drug development.

Clinical trials are not allowed; only U.S. small businesses are eligible.

--- ## Description This funding opportunity supports small businesses through the Small Business Innovation Research (SBIR) cooperative agreement mechanisms to develop miniaturized and automated tissue chip systems (MATChS). The goal is to enable the creation of tools and turnkey technologies for higher throughput, automated measurement with online sensing, rapid data acquisition, and analysis. The intent is to reduce manual handling and increase the availability of advanced tissue chip platforms for drug development and other biomedical research applications. Awardees will collaborate with NIH staff, develop milestones and benchmarks, and pursue commercialization pathways for their technologies. --- ## Due Dates - Application deadline: November 17, 2025 --- ## Funding Amount - Award ceiling and floor: Not specified on Grants.gov. - Funding amount and project duration will vary depending on the scope and phase of the project. - Program uses the SBIR U43/U44 cooperative agreement mechanisms. --- ## Eligibility - Eligible applicants are U.S. small businesses. - Non-domestic (non-U.S.) entities and foreign components are not eligible. - Non-domestic components of U.S. organizations are also not eligible. - Only U.S.-based small business concerns (SBCs) may apply. - Clinical trials are not allowed under this funding opportunity. --- ## Application Process - Applications must be submitted electronically via [Grants.gov](https://www.grants.gov/search-results-detail/351096). - Applicants should carefully review the full funding announcement for application instructions and required documentation. - Awardees will be expected to develop clear milestones and benchmarks and work in coordination with NIH staff throughout the project. --- ## Additional Information - This opportunity is a cooperative agreement, meaning substantial NIH involvement in project oversight and coordination. - Emphasis is placed on the development of automated, miniaturized tissue chip platforms with demonstrable commercialization potential. - For full details, refer to the [official program announcement](https://grants.nih.gov/grants/guide/rfa-files/RFA-TR-23-017.html). --- ## External Links - [Grants.gov Opportunity Listing](https://www.grants.gov/search-results-detail/351096) - [NIH Program Announcement and Details](https://grants.nih.gov/grants/guide/rfa-files/RFA-TR-23-017.html) --- ## Contact Information | Contact | Email | Notes | |----------------------------|---------------------------|----------------------------------------------------------------------------------------| | NIH Grants Information | grantsinfo@nih.gov | See Section VII. Agency Contacts in the full announcement for more details |

Miniaturization and Automation of Tissue Chip Systems (MATChS) (U43/U44 Clinical Trial Not Allowed)

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