[American Cancer Society](https://www.cancer.org)

June 1, 2026 | December 1, 2026

Stage I: up to $135,000/year direct costs + 10% indirect (max $297,000 total over 2 years); Stage II: up to $545,000 direct costs + 10% indirect (18 months)

Supports milestone-driven, innovative cancer research projects translating discoveries to human testing via a two-stage funding model.

No prior ACS funding required; open to independent investigators at any career stage.

--- ## Description Mission Boost Grants (MBG) from the American Cancer Society are designed to advance translational cancer research projects that emphasize moving discoveries toward human clinical testing. The program provides two stages of funding: Stage I supports the development of clear, outcome-specific milestones to reduce risks associated with new interventions, while Stage II funds the clinical testing of drugs, devices, or procedures in cancer patients. The grant is open to independent investigators at any career stage, offering a significant opportunity for innovative, clinical-enabling research. --- ## Due Dates - June 1, 2026: Full application deadline - December 1, 2026: Full application deadline If the deadline falls on a weekend or holiday, applications are accepted the next business day. --- ## Funding Amount - **Stage I:** Up to $135,000/year in direct costs plus 10% allowable indirect costs, for up to 2 years (maximum $297,000 total). - **Stage II:** Up to $545,000 in direct costs plus 10% allowable indirect costs, for up to 18 months. - Indirect costs are capped at 10% of direct costs (excluding permanent equipment). - Only one MBG may be held at a time, but other ACS grants are permitted if there is no scientific overlap. --- ## Eligibility - Applicants must be independent investigators with a full-time faculty appointment (or equivalent) at a US-based academic or eligible nonprofit institution. - All career stages are eligible. - No requirement for prior or current ACS funding. - For Stage II, applicants must have held a Stage I MBG for at least 18 months and completed all Stage I milestones. - Institutions must be not-for-profit and physically located in the US or its territories. - Applicants and mentors must not have current or pending tobacco industry funding. --- ## Application Process - Applications must be submitted electronically via [ProposalCentral](https://proposalcentral.com/). - Prepare all required documents per ACS guidelines, including project summaries, technical abstracts, budget, and biosketches. - Applications must be validated and submitted by 11:59 PM ET on the deadline. - Only one MBG application per applicant per cycle is allowed. - One resubmission is permitted if the initial application is not funded. - Contact the relevant ACS program office for questions about eligibility or the application process. --- ## Additional Information - MBG projects must focus on translational studies in cancer patients, including new treatments, diagnostics, devices, or prevention strategies. - Collaborations with industry partners are encouraged to maximize clinical impact. - Funded projects are expected to define clear, outcome-based milestones for each stage. - Intellectual property developed with MBG support is subject to ACS policies, including potential revenue sharing if commercialization occurs. - Progress reports and financial reports are required annually and at the end of the grant. --- ## External Links - [Mission Boost Grants (MBG) Program Page](https://www.cancer.org/research/we-fund-cancer-research/apply-research-grant/grant-types/mission-boost-grants.html) - [ACS Grant Application Portal (ProposalCentral)](https://proposalcentral.com/) - [ACS Grant Policies & Guidelines (PDF)](https://www.cancer.org/content/dam/cancer-org/research/extramural-grants-documents/all-grant-policies.pdf) - [ACS Grant Application Instructions (PDF)](https://www.cancer.org/content/dam/cancer-org/research/extramural-grants-documents/all-grant-instructions.pdf) - [Extramural Grants Staff Contacts](https://www.cancer.org/research/we-fund-cancer-research/apply-research-grant/extramural-grants-staff-contacts.html) --- ## Contact Information | Role/Office | Name/Contact | Email/Link | |----------------------------|---------------------------------------|---------------------------------------------| | General Grants Inquiries | ACS Grants Office | [grants@cancer.org](mailto:grants@cancer.org) | | Biochemistry & Immunology | Dr. Doug Hurst (Scientific Director) | [Santina Snow, PhD](mailto:santina.snow@cancer.org) (Senior Associate Scientist) | | Grants Applications Support| ProposalCentral Helpdesk | pcsupport@altum.com / 1-800-875-2562 | | General ACS Info | ACS Contact Center | +1 800-227-2345 | For detailed program office contacts, see the [ACS Extramural Discovery Science Contacts page](https://www.cancer.org/research/we-fund-cancer-research/apply-research-grant/extramural-grants-staff-contacts.html).

Mission Boost Grants (MBG)

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