Description

The National Biomedical Research Centers (NBRCs) program funds large-scale centers to provide advanced scientific expertise, state-of-the-art equipment, research infrastructure, and well-characterized research models to the biomedical research community nationwide. This initiative emphasizes the development of innovative human-based models and new technologies designed to reduce, refine, and replace the use of live animal models in biomedical research. Applications must include actionable plans for advancing complementary and alternative approaches, particularly New Approach Methodologies (NAMs), such as sophisticated in vitro and in silico models. NBRCs are expected to serve as both innovation hubs in fundamental science and as translational centers that develop and test interventions for human health. Clinical trials are allowed only when they utilize human-based NAMs. This is an open competition, including for centers with existing nonhuman primate colonies, and aims to leverage and expand capabilities in both basic and translational biomedical research.