Funder: National Institutes of Health
Due Dates: May 25, 2025 (New/Renewal/Resubmission/Revision) | September 7, 2025 (AIDS) | September 25, 2025 (New/Renewal/Resubmission/Revision) | January 7, 2026 (AIDS) | January 25, 2026 (New/Renewal/Resubmission/Revision) | May 7, 2026 (AIDS)
Funding Amounts: No budget cap; budgets must reflect actual needs. Maximum project period: 5 years.
Summary: Supports integrated, multi-project cancer research programs (P01) with at least three interrelated projects and an Administrative Core; clinical trials are optional.
Key Information: Applications must align with updated NCI priorities as of March 2025; at least three research projects and an Administrative Core are required.
This opportunity from the National Cancer Institute (NCI), part of the NIH, invites applications for investigator-initiated Program Project (P01) grants. The P01 mechanism supports integrated, multi-project research programs in any area of cancer research, including but not limited to cancer biology, prevention, diagnosis, treatment, and control. Each application must include at least three scientifically meritorious and interrelated research projects that share a common central theme, focus, or overall objective, as well as an Administrative Core. Optional Shared Resource Cores may be included if they support at least two projects.
The intent is to foster collaborative, multidisciplinary research that leverages synergy among projects and cores, accelerating progress beyond what could be achieved by individual projects alone. Both basic and applied (translational, clinical, or population-based) research are eligible. Clinical trials are optional.
Note: The funding opportunity was updated in March 2025 to align with current NCI priorities. Applicants should review the full announcement for recent changes and ensure their applications are responsive to updated requirements.
All applications are due by 5:00 PM local time of the applicant organization. Letters of intent are requested 30 days prior to the application due date.
Applicants requesting $500,000 or more in direct costs in any year must contact a Scientific/Research Contact at least six weeks before submission.
Eligible organizations include:
Not eligible: Non-domestic (non-U.S.) entities and non-domestic components of U.S. organizations. However, foreign components as defined in the NIH Grants Policy Statement are allowed.
Individuals: Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as PD(s)/PI(s) may apply. Multiple PD/PI applications are encouraged.
| Topic | Contact Name/Office | Email/Phone |
|---|---|---|
| General Grants Info | NIH Grants Information | GrantsInfo@nih.gov / 301-480-7075 |
| Scientific/Research Contact | NCI Referral Officer | ncirefof@dea.nci.nih.gov / 240-276-6390 |
| Peer Review Contact | NCI Referral Officer | ncirefof@dea.nci.nih.gov / 240-276-6390 |
| Financial/Grants Management | Crystal Wolfrey (NCI) | wolfreyc@mail.nih.gov / 240-276-6277 |
| Application Submission Help | eRA Service Desk | eRA Service Desk / 301-402-7469 or 866-504-9552 |
| Grants.gov Support | Grants.gov Customer Support | support@grants.gov / 800-518-4726 |