Feasibility Clinical Trials of Mind and Body Interventions for NCCIH High Priority Research Topics (R34 Clinical Trial Required)
Supporting feasibility trials of mind and body interventions for high-priority health conditions to inform future clinical trials for enhanced public health impact.
Funder: National Institutes of Health
Due Dates: June 20, 2025 (New/Renewal/Resubmission/Revision) | July 15, 2025 (AIDS) | October 20, 2025 (New/Renewal/Resubmission/Revision) | November 18, 2025 (AIDS) | February 20, 2026 (New/Renewal/Resubmission/Revision) | March 17, 2026 (AIDS) | June 22, 2026 (New/Renewal/Resubmission/Revision) | July 14, 2026 (AIDS) | October 20, 2026 (New/Renewal/Resubmission/Revision) | November 17, 2026 (AIDS)
Funding Amounts: Up to $450,000 direct costs over 3 years; no more than $225,000 direct costs in any single year.
Summary: Supports feasibility clinical trials of mind and body interventions for NCCIH high-priority health topics to inform future full-scale clinical trials.
Key Information: Only U.S.-based organizations are eligible to apply; foreign components are allowed but not as primary applicants.
Description
This opportunity, offered by the National Center for Complementary and Integrative Health (NCCIH) at NIH, funds feasibility clinical trials of mind and body interventions for conditions identified as high-priority research topics by NCCIH. The goal is to generate critical data needed to design and plan future, fully powered clinical efficacy, effectiveness, or implementation trials. Projects should address gaps in knowledge that are necessary for the development of competitive, full-scale clinical trials with the potential for significant public health impact.
Feasibility trials may focus on:
- Assessing the acceptability and adherence to interventions.
- Tailoring or adapting interventions for specific populations, modalities, or settings.
- Refining intervention protocols (e.g., frequency, duration).
- Testing recruitment, retention, and data collection procedures.
- Developing and testing multi-component interventions.
- Evaluating control conditions for future studies.
Applications must clearly justify the need for feasibility data and demonstrate that the proposed work is not duplicative of existing or ongoing studies. The subsequent full-scale trial should be well described in the application, and the feasibility study must be scientifically necessary for its planning.
