NHLBI Program Project Applications (P01 Clinical Trials Optional)
The NHLBI Program Project Grant supports research on heart, lung, and blood-related diseases, including implementation science and health disparities, through multiple projects addressing a central theme to accelerate knowledge acquisition, encourage new scientific directions, and support emerging scientific leaders.
Funder: National Institutes of Health
Due Dates: May 25, 2025 | September 25, 2025 | January 25, 2026 | May 25, 2026 | September 25, 2026
Funding Amounts: Up to $1,515,000 in direct costs per year (or $1,765,000 if including an ESI-led project with ≥4 projects); maximum project period 5 years.
Summary: Supports multi-project, collaborative research on heart, lung, blood, and sleep diseases, including implementation science and health disparities, with a focus on integrated, innovative programs addressing a central NHLBI mission theme.
Key Information: Applicants requesting ≥$500,000/year in direct costs must contact NHLBI at least 6 weeks before submission; clinical trials are optional but Phase III/IV trials are not allowed.
Description
This opportunity from the National Heart, Lung, and Blood Institute (NHLBI) supports investigator-initiated Program Project (P01) applications. The program funds integrated, collaborative research programs addressing fundamental processes and diseases of the heart, blood and lymphatic vessels, lungs, and blood—including transfusion medicine, blood resources, and sleep disorders. Projects may also address implementation science, health disparities, and translational research relevant to the NHLBI mission.
Each application must include at least three interrelated research projects that share a central theme, focus, or objective. Projects may be supported by shared scientific or administrative cores if justified. NHLBI encourages new scientific directions and the inclusion of scientists not traditionally supported by NHLBI, as well as opportunities for Early Stage Investigators (ESIs) to lead a project.
The program is designed to accelerate knowledge acquisition through collaborative, synergistic research that would not be as effective if conducted as separate projects.
