Funder: National Institutes of Health

Due Dates: February 5, 2025 (New) | March 5, 2025 (Renewal/Resubmission/Revision) | June 5, 2025 (New) | July 5, 2025 (Renewal/Resubmission/Revision) | October 5, 2025 (New) | November 5, 2025 (Renewal/Resubmission/Revision) | January 28, 2026 (Final closing/expiration)

Funding Amounts: No set budget limit; budgets should reflect project needs; max project period is 5 years.

Summary: Supports investigator-initiated, high-risk multi-center therapeutic clinical trials relevant to NIDDK’s mission, aiming to change clinical practice and/or public health.

Key Information: Planning activities must be completed prior to application; consult NIDDK staff before applying.