[National Institutes of Health](https://www.nih.gov/)

January 5, 2026 (estimated, forecasted)

Award size varies by phase and project; no explicit ceiling or floor specified

Supports U.S. small businesses in collaborative R&D projects with nonprofit research institutions to advance health-related technologies requiring clinical trials.

This is a forecasted opportunity; dates and details may change pending program reauthorization.

--- ## Description This opportunity, offered by the National Institutes of Health (NIH), is designed to support United States small business concerns (SBCs) through the Small Business Technology Transfer (STTR) program. The grant targets small businesses collaborating with nonprofit research institutions to conduct research and development (R&D) projects focused on health and clinical trial requirements. Participating NIH Institutes and Centers span a wide range of health domains, including aging, mental health, cancer, child health, and more. The program will utilize the R41/R42 activity codes, supporting Phase I, Phase II, Fast-Track, and Phase IIB applications. The goal is to foster innovation and translation of promising health-related technologies from the laboratory to the market, with a particular emphasis on projects that require clinical trials. --- ## Due Dates - Estimated Application Due Date: January 5, 2026 *All dates are projected based on the annual cycle; check the program page for updates.* --- ## Funding Amount - Award size and duration vary by phase (Phase I, Phase II, Fast-Track, Phase IIB). - No explicit award ceiling or floor specified in the current forecast. - Funding is contingent on the reauthorization and extension of the STTR program. --- ## Eligibility - Only United States small business concerns (SBCs), as defined by the Small Business Administration ([SBA eligibility guidelines](https://www.sbir.gov/apply)), are eligible to apply. - SBCs must collaborate with a U.S. nonprofit research institution. - Applicants must have the research capabilities and technological expertise to contribute to the NIH's R&D mission. - Other eligibility criteria may apply as detailed in the final Notice of Funding Opportunity (NOFO) when published. --- ## Application Process - Applications are not being solicited at this time; this is a forecasted opportunity. - The official solicitation will be published contingent upon reauthorization of the STTR program. - Researchers are encouraged to begin developing collaborations and project concepts in anticipation of the upcoming NOFO. - When the NOFO is released, applications will be submitted via [Grants.gov](https://www.grants.gov/). --- ## Additional Information - Multiple NIH Institutes and Centers participate, including NEI, NHLBI, NHGRI, NIA, NIAAA, NIBIB, NICHD, NIDA, NIDCD, NIEHS, NIMH, NINR, NIMHD, NLM, NCCIH, NCI, and ORWH. - The opportunity is focused on projects requiring clinical trials. - No cost sharing or matching is required. - Notice is being provided early to allow sufficient time for collaboration and project planning. --- ## External Links - [Opportunity Forecast on Grants.gov](https://www.grants.gov/search-results-detail/359670) - [NIH SEED (Small business Education and Entrepreneurial Development)](https://seed.nih.gov/) - [SBA SBIR/STTR Eligibility Information](https://www.sbir.gov/apply) --- ## Contact Information | Contact | Email | Phone | |------------------------|------------------------------|---------------| | NIH SEED Office (OER) | [SEEDinfo@nih.gov](mailto:SEEDinfo@nih.gov) | 301-827-8595 |

PHS 2025-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Required)

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