Complex Integrated Multi-Component Projects in Aging Research (U19 Clinical Trial Optional)
Grant opportunity for large-scale, complex aging research projects with integrated components and multidisciplinary teams.
This grant is no longer accepting proposals
National Institutes of Health has archived this opportunity.
Funder: National Institutes of Health
Due Dates: May 25, 2025 (New, Renewal, Resubmission, Revision) | September 25, 2025 (New, Renewal, Resubmission, Revision)
Funding Amounts: No budget cap; budgets must reflect actual project needs. Maximum project period: 5 years. Cooperative agreement (U19 mechanism).
Summary: Supports large-scale, complex, multi-component research projects addressing a common question in aging, requiring multidisciplinary teams and integrated approaches.
Key Information: Applicants must contact NIA program staff 2–3 months before submission; clinical trial optional; limited submission—see eligibility.
Description
This opportunity supports ambitious, large-scale, and complex research projects in the field of aging. Projects must consist of multiple, highly integrated components (such as research projects, cores, and coordinating centers) that collectively address a unified scientific question relevant to aging. The mechanism is designed for studies that are too complex for traditional single-project grants (e.g., R01), and typically require multidisciplinary teams, multiple sites, and/or specialized cores.
Examples of supported research include:
- Large-scale longitudinal studies integrating clinical, molecular, and genetic data in aging populations.
- Multi-site intervention studies in humans or animal models to test gerotherapeutic interventions.
- Multidisciplinary geroscience projects to elucidate mechanisms of aging and identify clinical targets.
- Behavioral and social science studies examining risk/protective factors for health outcomes in older adults.
- Translational projects moving basic science findings into clinical or community settings.
Projects must be tightly coordinated, with all components contributing to the overarching research question. Both clinical trial and non-clinical trial applications are accepted.
