CCRP Initiative: NIH Countermeasures Against Chemical Threats (CounterACT) Translational Exploratory/Developmental Research Projects (R21 Clinical Trial Not Allowed)
Funding supports research for new treatments against chemical threats- including translational studies for novel medical countermeasures.
This grant is no longer accepting proposals
National Institutes of Health has archived this opportunity.
Funder: National Institutes of Health
Due Dates: April 30, 2025 (Letter of Intent) | May 30, 2025 (Full Application, Renewal/Resubmission/Revision)
Funding Amounts: Up to $275,000 in direct costs over 2 years; no more than $200,000 in any single year.
Summary: Supports translational exploratory/developmental research to advance novel medical countermeasures for acute exposure to highly toxic chemical threats.
Key Information: Clinical trials are not allowed; projects must focus on preclinical development of treatments for acute, not chronic, chemical exposures.
Description
This funding opportunity supports translational exploratory and developmental research projects that directly advance the discovery of novel treatment strategies—medical countermeasures (MCMs)—to address serious morbidity and mortality following acute exposure to highly toxic chemical threats. These threats include chemical warfare agents, toxic industrial chemicals, pesticides, and ultra-potent synthetic opioids, which may be used in terrorist attacks or accidentally released.
The program is part of the NIH Countermeasures Against Chemical Threats (CounterACT) initiative, aiming to generate preliminary data that will facilitate the development of competitive applications for more extensive support. Projects may involve the discovery and validation of new molecular entities or biologics, repurposing of FDA-approved products, or combination interventions based on established mechanisms of action.
Only translational research directly related to the preclinical development of novel treatment strategies for acute chemical exposures is supported. Basic mechanistic studies, environmental decontamination, and analytical detection technology development are not eligible.
