Collaborative Program Grant for Multidisciplinary Teams (RM1 - Clinical Trial Optional)
Grant supports collaborative research teams of 3-6 investigators to tackle ambitious questions in line with NIGMS mission, requiring strong synergy, strategic interactions, and resulting in significant breakthroughs; not appropriate for community resources, new technologies, or clinical trials for safety and efficacy testing.
Funder: National Institutes of Health
Due Dates: May 27, 2026 (Full application) | April 27, 2026 (Letter of Intent) | January 27, 2026 (Full application) | December 28, 2025 (Letter of Intent) | May 28, 2025 (Full application) | April 28, 2025 (Letter of Intent) | January 28, 2025 (Full application) | December 29, 2024 (Letter of Intent)
Funding Amounts: Up to $1.5M direct costs/year (most awards $700k–$900k); project period up to 5 years; optional $250k/year for ESI developmental funds (years 2–5).
Summary: Supports highly integrated multidisciplinary research teams (3–6 PD/PIs) tackling ambitious biomedical questions within the NIGMS mission, beyond the scope of individual projects.
Key Information: Only U.S.-based organizations may apply; foreign components allowed but not as lead.
Description
This opportunity funds highly integrated, multidisciplinary research teams to address complex, ambitious biomedical questions that cannot be resolved by individual investigators or smaller collaborations. The program is designed to foster synergy, team management, and collective scientific advances within the mission of the National Institute of General Medical Sciences (NIGMS). Projects must be cohesive and go beyond the sum of individual efforts, with a team of three to six Program Directors/Principal Investigators (PD/PIs) collaborating on unified, high-impact objectives. Applications focused primarily on resource creation, infrastructure, or technology development are not appropriate.
