Competing Revisions to Existing NIH Single Project Research Grants and Cooperative Agreements (Clinical Trial Optional)

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Description

This opportunity allows current NIH award recipients to apply for additional funding to expand the scope of their existing single project research grants or cooperative agreements. These "competing revisions" (formerly known as competitive supplements) are intended to support new research aims or activities that build upon the parent award, in alignment with priorities outlined in a Notice of Special Interest (NOSI) published by an NIH Institute, Center, or Office (ICO). Both clinical trial and non-clinical trial projects are eligible, depending on the NOSI.

Applications must be directly responsive to a published NOSI referencing this funding announcement. The parent award must have at least two years remaining in its project period at the time of application.

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Due Dates

• Application deadlines are set by the specific NOSI to which you are responding.
• The overall funding opportunity expires on November 24, 2026.
• Applicants are encouraged to apply early to allow time for corrections.
• No standard letter of intent is required.

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Funding Amount

• Award size and duration: Determined by the specific NOSI and the needs of the proposed project. Typically, up to 2 years of additional support may be requested, but the project and budget period must fall within the currently approved project period of the parent award.
• Budget limits: May be specified in the NOSI; otherwise, budgets must be reasonable and justified for the proposed expansion.
• No cost sharing required unless specified in the NOSI.
• Number of awards: Contingent on NIH appropriations and the number of meritorious applications.

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Eligibility

• Who can apply: Only organizations and individuals with an active, eligible NIH single project research grant or cooperative agreement (e.g., R01, U01) may apply.
• Eligible organizations include:
  • Public and private higher education institutions
  • Nonprofits (with or without 501(c)(3) status)
  • For-profit organizations (including small businesses)
  • State, local, and tribal governments
  • Independent school districts, public housing authorities
  • Faith-based and community-based organizations
  • Regional organizations
  • Non-domestic (foreign) organizations and components
• Eligible individuals: Must be a PD/PI on the active parent award; for multi-PI awards, any or all PIs may apply per the leadership plan.
• Parent award requirements: Must have at least two years remaining in the current project period at the time of application.

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Application Process

• Step 1: Identify a relevant NOSI published by an NIH Institute, Center, or Office that references this funding opportunity.
• Step 2: Prepare a competitive revision application in accordance with the NIH Application Guide and the instructions in the NOSI.
• Step 3: Submit electronically via NIH ASSIST, Grants.gov Workspace, or your institution’s system-to-system solution.
• Step 4: Ensure all required registrations (SAM, eRA Commons, Grants.gov) are complete before submission.
• Step 5: Include the NOSI number in the application and select "Revision" as the application type.
• Step 6: Applications are peer reviewed for scientific and technical merit, then considered for funding based on program priorities and availability of funds.

Note: If requesting $500,000 or more in direct costs in any year, contact a Scientific/Research Contact at least 6 weeks before submission.

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Additional Information

• Only applications submitted in response to a published NOSI are eligible.
• The parent award’s terms and conditions apply to the revision.
• Foreign organizations and components are eligible.
• No cost sharing is required unless specified in the NOSI.
• Data Management and Sharing Plans must be addressed as appropriate.
• Clinical trials: Both clinical trial and non-clinical trial projects are eligible, depending on the NOSI.
• Reporting: Progress and financial reports are required as for the parent award.

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External Links

• NIH Funding Opportunity Announcement (PA-23-317)
• NIH Guide for Grants and Contracts: Notices of Special Interest (NOSIs)
• NIH Application Guide
• Grants.gov Opportunity Listing
• NIH Grants Policy Statement

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Contact Information

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