[National Institutes of Health](https://www.nih.gov)

November 2, 2028

Not specified; cooperative agreement mechanism; see NOFO for details.

Supports a Data Coordinating Center for investigator-initiated multi-site clinical trials relevant to NHLBI’s mission.

DCC and collaborating CCC applications must be submitted together on the same due date.

--- ## Description This opportunity funds a Data Coordinating Center (DCC) to support investigator-initiated, multi-site clinical trials—including efficacy, comparative effectiveness, pragmatic, and/or implementation research trials—aligned with the research mission of the National Heart, Lung, and Blood Institute (NHLBI). The DCC is expected to provide comprehensive project coordination, administration, data management, and biostatistical support. Innovative trial designs (platform, adaptive, Bayesian) are encouraged, and projects can address therapeutic, behavioral, or prevention strategies. The DCC will also work closely with a collaborating Clinical Coordinating Center (CCC) to implement the clinical trial’s community engagement plan. Both DCC and CCC applications must be submitted in parallel for consideration. --- ## Due Dates - November 2, 2028 *Both DCC and collaborating CCC applications must be submitted by this date.* --- ## Funding Amount - The award ceiling and floor are not specified in the announcement. - Funding is provided via a milestone-driven cooperative agreement. - Refer to the Notice of Funding Opportunity (NOFO) for detailed budget guidance. --- ## Eligibility Eligible applicants include: - State, county, city, or township governments - Special district governments - Independent school districts - Public and private institutions of higher education - Native American tribal governments (federally recognized and other) - Public housing authorities/Indian housing authorities - Nonprofits (with or without IRS 501(c)(3) status), excluding institutions of higher education - For-profit organizations (including small businesses) - Others as defined in the NOFO **Foreign organizations and non-U.S. components of U.S. organizations are eligible to apply.** **Foreign subawards/subcontracts involving NIH funding are not permitted under this NOFO.** Unfunded international collaborations or foreign consultants are allowed. --- ## Application Process - Applications must be submitted through [Grants.gov](https://www.grants.gov/search-results-detail/358938). - Both a DCC and a collaborating CCC application must be submitted on the same due date for consideration. - Applicants are strongly encouraged to contact the Scientific/Research contact prior to submission. - Refer to the full NOFO for detailed instructions and requirements. --- ## Additional Information - This NOFO runs in parallel with a companion opportunity (PAR-27-012) for the Clinical Coordinating Center. - Trials must be relevant to NHLBI’s mission and meet the NIH definition of a clinical trial. - Milestone-driven cooperative agreement mechanism is used. - For further details on eligibility, refer to Section III of the NOFO. --- ## External Links - [NIH Funder Page](https://www.nih.gov) - [Grant Opportunity on Grants.gov](https://www.grants.gov/search-results-detail/358938) - [NHLBI Website](https://www.nhlbi.nih.gov) --- ## Contact Information | Contact | Email | Phone | |---------|-------|-------| | Division of Cardiovascular Sciences | [NHLBIDCVSClinical@mail.nih.gov](mailto:NHLBIDCVSClinical@mail.nih.gov) | 301-496-4000 |

Data Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative U24 Clinical Trial Required)

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