Funder: National Institutes of Health
Due Dates: June 5, 2025 (New) | July 5, 2025 (Renewal/Resubmission/Revision) | September 7, 2025 (AIDS) | October 5, 2025 (New) | November 5, 2025 (Renewal/Resubmission/Revision) | January 7, 2026 (AIDS) | Standard NIH R01 due dates through January 7, 2028
Funding Amounts: No budget limit; project period up to 5 years; budgets must reflect actual needs.
Summary: Supports research to identify, develop, and test strategies for disseminating, implementing, and sustaining evidence-based health interventions, including de-implementation of ineffective practices.
Key Information: Clinical trials are optional; foreign and domestic organizations are eligible; all applications must align with the mission of a participating NIH Institute or Center.
Description
This opportunity supports research projects that advance the science of dissemination and implementation (D&I) in health. The focus is on identifying, developing, and testing strategies to overcome barriers to the adoption, adaptation, integration, sustainability, scale-up, and spread of evidence-based interventions, practices, programs, tools, treatments, guidelines, and policies. Projects may also address the de-implementation of ineffective, unproven, low-value, or harmful practices.
The program encourages studies that:
- Promote equitable dissemination and implementation among underrepresented or health-disparity populations.
- Advance D&I research methods and measures.
- Address re-implementation of evidence-based health services disrupted by disasters (e.g., pandemics, climate change).
- Explore economic evaluations, contextual factors, and stakeholder engagement in D&I.
Applications must be within the mission of at least one participating NIH Institute or Center. Multidisciplinary and stakeholder-engaged approaches are strongly encouraged.
Due Dates
- Next New Application Due: June 5, 2025
- Renewal/Resubmission/Revision: July 5, 2025
- AIDS-related Applications: September 7, 2025
- Subsequent cycles: Standard NIH R01 due dates through January 7, 2028
All applications are due by 5:00 PM local time of the applicant organization. Letters of intent are due 30 days prior to the application due date.
Funding Amount
- Budget: No upper limit; budgets must reflect the actual needs of the proposed project.
- Project Period: Up to 5 years.
- Number of Awards: Contingent on NIH appropriations and the number of meritorious applications.
Applicants requesting $500,000 or more in direct costs in any year must contact a Scientific/Research Contact at least 6 weeks before submission.
Eligibility
Eligible applicants include:
- Public and private institutions of higher education
- Nonprofits (with or without 501(c)(3) status)
- For-profit organizations (including small businesses)
- State, county, city, township, and special district governments
- Independent school districts
- Public housing authorities/Indian housing authorities
- Native American tribal governments and organizations (federally recognized and other)
- Faith-based and community-based organizations
- Regional organizations
- U.S. territories and possessions
- Non-domestic (non-U.S.) entities (foreign organizations)
Individuals with the skills, knowledge, and resources necessary to carry out the proposed research are eligible to apply as PD/PI.
Application Process
- Submission: Applications must be submitted electronically via Grants.gov using ASSIST, Grants.gov Workspace, or an institutional system-to-system solution.
- Required Registrations: Applicant organizations must have active registrations in SAM, eRA Commons, and Grants.gov. PDs/PIs must have an eRA Commons account.
- Application Guide: Follow the NIH SF424 (R&R) Application Guide and the specific instructions in the funding announcement (PAR-25-144).
- Clinical Trials: Applications may propose clinical trials but are not required to do so.
- Data Management and Sharing: All applications must include a Data Management and Sharing Plan.
Additional Information
- Scope: Applications must align with the mission of at least one participating NIH Institute or Center. Contact program staff early to ensure fit.
- Non-responsive Applications: Projects testing new therapies, imaging, diagnostics, biologics, or devices (e.g., first-in-human studies or efficacy trials) are not responsive.
- Review Criteria: Scientific merit, innovation, feasibility, investigator expertise, and potential for public health impact.
- Companion Opportunities: R21 (PAR-25-143) and R03 (PAR-25-233) are available for related exploratory and small research projects.
External Links
Contact Information
Scientific/Research Contacts (selected):
- National Cancer Institute: Gila Neta, PhD – Gila.Neta@nih.gov – 240-276-6785
- National Human Genome Research Institute: Alanna Kulchak Rahm, PhD – alanna.kulchakrahm@nih.gov – 720-989-9020
- National Institute on Alcohol Abuse and Alcoholism: Laura Kwako, PhD – laura.kwako@nih.gov – 301-451-8507
- National Institute on Drug Abuse: Lori Ducharme – lori.ducharme@nih.gov – 301-827-6331
- National Institute of Mental Health: Mary Acri, PhD – mary.acri@nih.gov – 301-910-8230
Full list of contacts by Institute/Center